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FLASH GENE
Symbol ABI3 contributors: - updated : 06-01-2006
HGNC name ABI gene family, member 3
HGNC id 29859
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   predominantly
 spleen   moderately
Reproductivefemale systemplacenta  moderately
Urinarykidney   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a homeobox homology domain
  • SH3 (Src-homology 3) domain
  • proline rich region, serine rich region and no catalytic domain
    • HOMOLOGY
    interspecies ortholog to murine Abi3
    intraspecies homolog to SSH3BP1
    Homologene
    FAMILY adaptor protein family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • colocalized with PAK2 at leading edge of cells
    • basic FUNCTION
  • inhibiting ectopic metastasis of tumor cells as well as cell migration
  • playing a role in cell growth signaling
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p21-activated kinase
  • NESHBP/TARSH
  • PAK1
  • PAK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    lost of expression in invasive cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS