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FLASH GENE
Symbol ABI3 contributors: - updated : 06-01-2006
HGNC name ABI gene family, member 3
HGNC id 29859
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunelymph node   predominantly
 spleen   moderately
Reproductivefemale systemplacenta  moderately
Urinarykidney   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a homeobox homology domain
  • SH3 (Src-homology 3) domain
  • proline rich region, serine rich region and no catalytic domain
    • HOMOLOGY
    interspecies ortholog to murine Abi3
    intraspecies homolog to SSH3BP1
    Homologene
    FAMILY adaptor protein family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • colocalized with PAK2 at leading edge of cells
    • basic FUNCTION
  • inhibiting ectopic metastasis of tumor cells as well as cell migration
  • playing a role in cell growth signaling
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p21-activated kinase
  • NESHBP/TARSH
  • PAK1
  • PAK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    lost of expression in invasive cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS