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FLASH GENE
Symbol ABI3 contributors: - updated : 06-01-2006
HGNC name ABI gene family, member 3
HGNC id 29859
Location 17q21.3      Physical location : 47.287.588 - 47.300.587
Synonym name
  • new molecule including SH3
  • NESH protein
    • Synonym symbol(s) NESH, SSH3BP3
    DNA
    TYPE functioning gene
    STRUCTURE 13.00 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   predominantly
     spleen   moderately
    Reproductivefemale systemplacenta  moderately
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a homeobox homology domain
  • SH3 (Src-homology 3) domain
  • proline rich region, serine rich region and no catalytic domain
    • HOMOLOGY
    interspecies ortholog to murine Abi3
    intraspecies homolog to SSH3BP1
    Homologene
    FAMILY adaptor protein family
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text
  • colocalized with PAK2 at leading edge of cells
    • basic FUNCTION
  • inhibiting ectopic metastasis of tumor cells as well as cell migration
  • playing a role in cell growth signaling
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p21-activated kinase
  • NESHBP/TARSH
  • PAK1
  • PAK2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    lost of expression in invasive cancer cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS