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FLASH GENE
Symbol TSNAX contributors: mct/np - updated : 30-12-2015
HGNC name translin-associated factor X
HGNC id 12380
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate  moderately
 male systemtestis   
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivesperm cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text kidney
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • N terminal bipartite nuclear targeting sequence
  • heptad repeat of hydrophobic AAs(leucine zipper structure)
  • a functional nuclear localization signal
    • mono polymer heteromer , hexamer
    HOMOLOGY
    interspecies homolog to murine Tsnax
    intraspecies homolog to translin
    Homologene
    FAMILY translin family
    CATEGORY DNA associated , RNA associated , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • localize in nuclei in meiotic pachytene spermatocytes and in the cytoplasm of subsequent meiotic and post-meiotic cells
  • is a cytosolic protein that can transit into the nucleus
    • basic FUNCTION
  • playing a role in TSN functions
  • playing a special role in spermatogenesis
  • TSN and TSNAX play a central and important role in eukaryotic cell biology
  • play roles in very important cellular processes such as DNA recombination, spatial and temporal expression of mRNA, and in siRNA processing
  • both translin and TSNAX are binding competent and contribute to the nucleic acid binding activity
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • TSN/TSNAX heteromultimers for modulation of DNA and RNA binding activity of translin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • coexpressed in testis and interacting with SUN1, AKAP9, GOLGA3, TSNAXIP1
  • interaction with TSN (the subcellular locations of TSN and TSNAX in male germ cells are modulated by the relative ratios of TSNAX and TSN)
  • ADORA2A modulates the differentiation ability of trophic factors through a novel interacting protein, TRAX
  • interacting with ADORA2A (Zezula 2008)
  • TSNAX, localized in the cytosol and nucleus, competes with plasma-membrane bound GNAQ for PLCB1 binding thus stabilizing PLCB1 in other cellular compartments
  • novel role of PLCB1 in gene regulation through TSNAX association
    • cell & other
    REGULATION
    Other post-transcriptionally regulated by its partner protein TSN, and both are essential for normal cell proliferation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   translocation    
    translocation t(1;11) (q42.1;q14.3) in a family of patients affeced by schizophrenia
    constitutional   translocation    
    five speciesof intergenic splicing, one yielding a fusion protein TSNAX/DISC1
    tumoral fusion      
    chimeric TSNAX-DISC1 occurred significantly upregulated in multiple endometrial carcinoma samples
    Susceptibility
  • to bipolar spectrum disorder
  • to autism spectrum disorders
    • Variant & Polymorphism other
  • polymorphisms increasing the risk of bipolar spectrum disorder
  • deleted in autism spectrum disorders (Williams 2009)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS