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FLASH GENE

Symbol

TSNAX

contributors: mct/np - updated : 30-12-2015

HGNC name	translin-associated factor X
HGNC id	12380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q42.2      Physical location : 231.664.398 - 231.702.267
Synonym name	testis-brain RNA-binding protein
	translin-associated protein X
Synonym symbol(s)	TRAX, TSNX

DNA

TYPE	functioning gene
STRUCTURE	37.87 kb     6 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	cytosine-phosphate-guanine/HTF
	Binding site
motif	repetitive sequence
text structure	DNA binding site

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - TSNAX - DISC1- DISC2 - D1S251 - qter
Authors	Millar (00)

RNA

TRANSCRIPTS	type	messenger

text	four major transcripts and transcript resulting from an intergenic splicing TRAX-DISC1 (Millar)

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005999 6 - 2667 NP_005990 33 290 - 2002 12036294

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver         Nervous brain         Reproductive male system prostate     moderately   male system testis       Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Reproductive sperm cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

kidney

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	N terminal bipartite nuclear targeting sequence
	heptad repeat of hydrophobic AAs(leucine zipper structure)
	a functional nuclear localization signal

mono polymer

heteromer , hexamer

HOMOLOGY

interspecies

homolog to murine Tsnax

intraspecies

homolog to translin

Homologene

FAMILY

translin family

CATEGORY

DNA associated , RNA associated , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	localize in nuclei in meiotic pachytene spermatocytes and in the cytoplasm of subsequent meiotic and post-meiotic cells
	is a cytosolic protein that can transit into the nucleus

basic FUNCTION	playing a role in TSN functions
	playing a special role in spermatogenesis
	TSN and TSNAX play a central and important role in eukaryotic cell biology
	play roles in very important cellular processes such as DNA recombination, spatial and temporal expression of mRNA, and in siRNA processing
	both translin and TSNAX are binding competent and contribute to the nucleic acid binding activity

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

nervous system , cellular trafficking transport

PATHWAY

metabolism

signaling

a component

TSN/TSNAX heteromultimers for modulation of DNA and RNA binding activity of translin

INTERACTION

DNA

RNA

small molecule

protein	coexpressed in testis and interacting with SUN1, AKAP9, GOLGA3, TSNAXIP1
	interaction with TSN (the subcellular locations of TSN and TSNAX in male germ cells are modulated by the relative ratios of TSNAX and TSN)
	ADORA2A modulates the differentiation ability of trophic factors through a novel interacting protein, TRAX
	interacting with ADORA2A (Zezula 2008)
	TSNAX, localized in the cytosol and nucleus, competes with plasma-membrane bound GNAQ for PLCB1 binding thus stabilizing PLCB1 in other cellular compartments
	novel role of PLCB1 in gene regulation through TSNAX association

cell & other

REGULATION

Other

post-transcriptionally regulated by its partner protein TSN, and both are essential for normal cell proliferation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   translocation     translocation t(1;11) (q42.1;q14.3) in a family of patients affeced by schizophrenia constitutional   translocation     five speciesof intergenic splicing, one yielding a fusion protein TSNAX/DISC1 tumoral fusion       chimeric TSNAX-DISC1 occurred significantly upregulated in multiple endometrial carcinoma samples

Susceptibility

to bipolar spectrum disorder to autism spectrum disorders

Variant & Polymorphism other	polymorphisms increasing the risk of bipolar spectrum disorder
	deleted in autism spectrum disorders (Williams 2009)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS