protein
| Binds K-RAS and N-RAS |
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interacts directly with Ras but not with the Ras(P34G) mutant protein (Sieburth 1998) |
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interacts with ERBB2IP via its LRR domain (Dai 2006) |
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ERBIN inhibits RAS-mediated activation of the extracellular signal-regulated kinase (ERK) by binding to Soc-2 suppressor of clear homolog (SHOC2) |
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HUWE1 is a binding partner and regulator of SHOC2 function |
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MRAS specifically functions within the Ras/MAPK pathway by forming a ternary complex with SHOC2 and PP1 |
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MRAS and SHOC2 function as PPP1CB regulatory subunits providing the complex with striking specificity against RAF ( |