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FLASH GENE
Symbol SHOC2 contributors: mct/npt - updated : 16-12-2016
HGNC name soc-2 suppressor of clear homolog (C. elegans)
HGNC id 15454
Corresponding disease
NLLAH Noonan-like syndrome with loose anagen hair
Location 10q25      Physical location : 112.679.300 - 112.773.424
Synonym name
  • leucine-rich protein,homolog to C elegans soc2
  • Ras-binding protein Sur-8
  • weakly similar to contains similarity to leucine-rich repeats
    • [C.elegans]
    Synonym symbol(s) SOC2, SUR8, SOC-2, SUR-8, KIAA0862, SIAA0862
    DNA
    TYPE functioning gene
    STRUCTURE 94.12 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3962 64 582 - Sieburth (1998)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal lysine-rich region (Cordeddu 2009)
  • composed predominantly of 19 leucine-rich repeats, leucine-rich protein with two YXNX motifs (Sieburth 1998)
    • HOMOLOGY
    interspecies homolog to C.elegans soc2(suppressor of clear (clr-1))
    homolog to murine Shoc2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • implicated in fibroblast growth receptor signaling
  • may mediate its effects through Ras binding (Sieburth 1998)
  • its function is essential for activation of the MAPK pathway by growth factors (Rodriguez-Viciana 2006)
  • leucine-rich repeat–containing protein that positively modulates RAS-MAPK signal flow (Cordeddu 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Binds K-RAS and N-RAS
  • interacts directly with Ras but not with the Ras(P34G) mutant protein (Sieburth 1998)
  • interacts with ERBB2IP via its LRR domain (Dai 2006)
  • ERBIN inhibits RAS-mediated activation of the extracellular signal-regulated kinase (ERK) by binding to Soc-2 suppressor of clear homolog (SHOC2)
  • HUWE1 is a binding partner and regulator of SHOC2 function
  • MRAS specifically functions within the Ras/MAPK pathway by forming a ternary complex with SHOC2 and PP1
  • MRAS and SHOC2 function as PPP1CB regulatory subunits providing the complex with striking specificity against RAF (
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NLLAH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS