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FLASH GENE

Symbol

SHOC2

contributors: mct/npt - updated : 16-12-2016

HGNC name	soc-2 suppressor of clear homolog (C. elegans)
HGNC id	15454

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	94.12 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007373 9 - 3962 NP_031399 64 582 - Sieburth (1998)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal lysine-rich region (Cordeddu 2009)
	composed predominantly of 19 leucine-rich repeats, leucine-rich protein with two YXNX motifs (Sieburth 1998)

HOMOLOGY

interspecies	homolog to C.elegans soc2(suppressor of clear (clr-1))
	homolog to murine Shoc2

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	implicated in fibroblast growth receptor signaling
	may mediate its effects through Ras binding (Sieburth 1998)
	its function is essential for activation of the MAPK pathway by growth factors (Rodriguez-Viciana 2006)
	leucine-rich repeat–containing protein that positively modulates RAS-MAPK signal flow (Cordeddu 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	Binds K-RAS and N-RAS
	interacts directly with Ras but not with the Ras(P34G) mutant protein (Sieburth 1998)
	interacts with ERBB2IP via its LRR domain (Dai 2006)
	ERBIN inhibits RAS-mediated activation of the extracellular signal-regulated kinase (ERK) by binding to Soc-2 suppressor of clear homolog (SHOC2)
	HUWE1 is a binding partner and regulator of SHOC2 function
	MRAS specifically functions within the Ras/MAPK pathway by forming a ternary complex with SHOC2 and PP1
	MRAS and SHOC2 function as PPP1CB regulatory subunits providing the complex with striking specificity against RAF (

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NLLAH

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS