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FLASH GENE
Symbol ENTPD8 contributors: npt/ - updated : 22-11-2005
HGNC name ectonucleoside triphosphate diphosphohydrolase 8
HGNC id 24860
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2222 53.8 495 - Knowles (2006)
9 - 2111 49.3 458 - Knowles (2006)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
 liver    
 pancreas exocrine   moderately
Reproductivemale systemtestis  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Entpd8
Homologene
FAMILY
  • GDA1/CD39 NTPase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • responsible for the major ectonucleotidase activity in liver
  • involved in the regulation of bile secretion and/or nucleoside salvage (Fausther 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS