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Symbol ENTPD8 contributors: npt/ - updated : 22-11-2005
HGNC name ectonucleoside triphosphate diphosphohydrolase 8
HGNC id 24860
Location 9q34.3      Physical location : 140.328.816 - 140.335.901
Synonym name
  • ecto-ATP-diphosphohydrolase
  • liver ecto-ATP-diphosphohydrolase
  • Synonym symbol(s) GLSR2492, NTPDase-8, UNQ2492
    EC.number 3.6.1.5
    DNA
    TYPE functioning gene
    STRUCTURE 7.09 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2222 53.8 495 - Knowles (2006)
    9 - 2111 49.3 458 - Knowles (2006)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     liver    
     pancreas exocrine   moderately
    Reproductivemale systemtestis  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Entpd8
    Homologene
    FAMILY
  • GDA1/CD39 NTPase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • responsible for the major ectonucleotidase activity in liver
  • involved in the regulation of bile secretion and/or nucleoside salvage (Fausther 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS