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FLASH GENE
Symbol CDS2 contributors: npt/mct - updated : 28/10/2008
HGNC name CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
HGNC id 1801
DNA
TYPE like-sequence
STRUCTURE 64.50 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 9500 - - - Volta, 99
- - - 4400 - - - Volta, 99
13 - 2711 - 445 - Olsen (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveesophagus   highly
 liver    
Endocrinepancreas    
Lymphoid/Immunethymus   highly
Nervousnerve   highly
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage in the differentiating neuroblasts of the neural retina
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text highly expressed in the differentiating neuroblasts of the neural retina and in the central nervous system during embryonic development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine transmembrane domains
  • HOMOLOGY
    interspecies homolog to Drosophila cds
    homolog to murine Cds2
    homolog to C.elegans c33h5.18
    homolog to Drosophila cdp
    intraspecies homolog to CDS1
    Homologene
    FAMILY
  • CDS family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text matrix side of the inner mitochondrial membrane
    basic FUNCTION
  • converting phosphatidic acid in CDP (cytidine diphosphate) DAG (dicylglycerol) regulator of cellular phosphatidylinositol content
  • be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis
  • required for phototransduction
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
  • involved in phosphoinositide mediated signaling pathway, phospholipid biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS