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FLASH GENE

Symbol

CDS2

contributors: npt/mct - updated : 28/10/2008

HGNC name	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
HGNC id	1801

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p13      Physical location : 5.107.481 - 5.171.987
Synonym name	CTP:phosphatidate cytidylyltransferase 2
	CDP-DAG synthase 2
Synonym symbol(s)	FLJ38111, RP4-680N4.2
EC.number	2.7.7.41

DNA

TYPE	like-sequence
STRUCTURE	64.50 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed - - - 9500 - - - Volta, 99 - - - 4400 - - - Volta, 99 variant 1 13 - 2711 - 445 - Olsen (2006)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive esophagus       highly   liver         Endocrine pancreas         Lymphoid/Immune thymus       highly Nervous nerve       highly Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum cardiac     Muscular striatum skeletal     Nervous central

cell lineage	in the differentiating neuroblasts of the neural retina
cell lines
fluid/secretion

at STAGE

physiological period

embryo, pregnancy

Text	highly expressed in the differentiating neuroblasts of the neural retina and in the central nervous system during embryonic development

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

nine transmembrane domains

HOMOLOGY

interspecies	homolog to Drosophila cds
	homolog to murine Cds2
	homolog to C.elegans c33h5.18
	homolog to Drosophila cdp

intraspecies

homolog to CDS1

Homologene

FAMILY

CDS family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	matrix side of the inner mitochondrial membrane

basic FUNCTION	converting phosphatidic acid in CDP (cytidine diphosphate) DAG (dicylglycerol) regulator of cellular phosphatidylinositol content
	be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis
	required for phototransduction

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

lipid/lipoprotein

signaling

signal transduction

involved in phosphoinositide mediated signaling pathway, phospholipid biosynthesis

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Mg2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS