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FLASH GENE
Symbol ATP6V0E2 contributors: - updated : 31-08-2007
HGNC name ATPase, H+ transporting V0 subunit E
HGNC id 21723
DNA
TYPE like-sequence
STRUCTURE 7.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   predominantly
 nervecranial nerve  highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal region contains YVRF
  • a potential YXXØ motif that is not present in ATP6V0E1
    • HOMOLOGY
    interspecies homolog to murine Atp6v0e2
    ortholog to yeast Vma9p
    Homologene
    FAMILY V-ATPase E subunit family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play an important role in the intracellular localization and activity of H+-ATPases
  • vacuolar atpase is responsible for acidifying a variety of intracellular compartment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text proton
    PATHWAY
    metabolism
    signaling
    a component at least 10 subunits
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS