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FLASH GENE
Symbol ATP6V0E2 contributors: - updated : 31-08-2007
HGNC name ATPase, H+ transporting V0 subunit E
HGNC id 21723
Location 7q36.1      Physical location : 149.570.056 - 149.577.786
Synonym name
  • vacuolar protein, ATPase subunit
  • chromosome 7 open reading frame 32
    • Synonym symbol(s) C7orf32, ATP6V0E2L
    DNA
    TYPE like-sequence
    STRUCTURE 7.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   predominantly
     nervecranial nerve  highly
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal region contains YVRF
  • a potential YXXØ motif that is not present in ATP6V0E1
    • HOMOLOGY
    interspecies homolog to murine Atp6v0e2
    ortholog to yeast Vma9p
    Homologene
    FAMILY V-ATPase E subunit family
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play an important role in the intracellular localization and activity of H+-ATPases
  • vacuolar atpase is responsible for acidifying a variety of intracellular compartment
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text proton
    PATHWAY
    metabolism
    signaling
    a component at least 10 subunits
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS