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FLASH GENE

Symbol

HEMK1

contributors: KTN/NPT - updated : 24/11/2008

HGNC name	HemK methyltransferase family member 1
HGNC id	24923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3p21.31      Physical location : 50.606.908 - 50.622.419
Synonym name	HEMK homolog 7kb
Synonym symbol(s)	MTQ1, HEMK, FLJ22320, HMPrmC
EC.number	2.1.1.-

DNA

TYPE	functioning gene
STRUCTURE	15.51 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed HEMK1 11 - 5862 38.1 338 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine thyroid       highly Lymphoid/Immune lymph node       predominantly   thymus         Reproductive female system uterus cervix   moderately Urinary kidney       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to murine Hemk1 (77.8 pc)
	homolog to dog HEMK1 (85.2 pc)
	homolog to cow HEMK1 (82.2 pc)
	homolog to rattus Hemk1 (79 pc)
	homolog to chicken HEMK1 (58.4 pc)

Homologene

FAMILY

hemK family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	acting as an N-methyltransferase
	methylating the glutamine residue in the GGQ tripeptide motif of HMRF1L

CELLULAR PROCESS

nucleotide, chromatin organization, methylation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS