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FLASH GENE
Symbol CD3EAP contributors: - updated : 28-03-2006
HGNC name CD3e antigen, epsilon polypeptide associated protein
HGNC id 24219
Location 19q13.3      Physical location : 45.909.466 - 45.914.024
Synonym name
  • CD3-epsilon-associated protein
  • antisense to ERCC1 protein
  • RNA polymerase I-associated factor PAF49
  • Synonym symbol(s) CAST, ASE-1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping, antisens
    text overlapping the 3'UTR of ERCC1, in opposed orientation
    STRUCTURE 4.00 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, interphase, M
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a glycine-arginine-phenylalanine rich putative nucleotide interaction domain and an alternating basic/acid region,a phosphorylation site
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • fibrillar centres of the nucleolus in interphase
  • at nucleolus organizer regions of the chromosome during mitosis
  • basic FUNCTION
  • activating signals upon TCR signalization
  • involved in nucleolar function
  • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS development
    text thymus development
    PATHWAY
    metabolism
    signaling signal transduction
    signaling pathway via CD3 epsilon-containing TCR signaling molecule
    a component componentof a preformed TCR complex
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
  • colocolizing and associating with RNA polymerase I transcription initiation factor,UBF/NOR90,throughout the cell cycle
  • interacting with CD3 epsilon
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS