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FLASH GENE

Symbol

TASP1

contributors: mct - updated : 11-12-2006

HGNC name	taspase, threonine aspartase, 1
HGNC id	15859

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20p12.1      Physical location : 13.370.036 - 13.619.583
Synonym name	chromosome 20 open reading frame 13
	threonine aspartase 1
Synonym symbol(s)	FLJ20212, dJ585I14.2, MGC39159, C20orf13
EC.number	3.4.25.-

DNA

TYPE	functioning gene
STRUCTURE	249.55 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	several alternate transcripts

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_017714 14 - 2368 NP_060184 - 420 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine neuroendocrine pituitary     highly Reproductive female system ovary       Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

asparaginase 2 homology domain

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to Drosophila CG5241

Homologene

FAMILY	asparaginase family
	Ntn-hydrolase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	cleaving specific substrates following aspartate residues
	required for proper HOX gene expression and for cleavage of MLL and TFIIA

CELLULAR PROCESS

protein, degradation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MLL
	interacting wit GTF2A1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS