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FLASH GENE
Symbol SCAF1 contributors: npt - updated : 25-07-2005
HGNC name SR-related CTD-associated factor 1
HGNC id 30403
Location 19q13.3-q13.4      Physical location : 50.145.381 - 50.161.905
Synonym name
  • serine-arginine-rich pre-mRNA splicing factor
  • SR-related-CTD-associated factor
  • splicing factor, arginine/serine-rich 19
  • Synonym symbol(s) SR-A1, SRAR1, FLJ00034, SFRS19, SCAF
    DNA
    TYPE functioning gene
    STRUCTURE 21.00 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4207 139 1312 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen    
    Nervousbrain   highly
    Skin/Tegumentskin    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain and liver highly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one SR-rich domain
  • one CTD-binding domain
  • HOMOLOGY
    interspecies homolog to rattus A1 gene
    Homologene
    FAMILY
  • Ser/Arg rich family
  • splicing factor SR family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may be playing an important role in regulation of brain function and neural differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by estrogens, androgens ans glucocortico
    ds (in cancer lines)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian cancer (more agressive)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS