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FLASH GENE
Symbol ADCYAP1 contributors: mct/npt - updated : 29-12-2020
HGNC name adenylate cyclase activating polypeptide 1 (pituitary)
HGNC id 241
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional       gain of function
following nerve decompression, and its and its expression was associated with recovery of intraepidermal nerve fibres
constitutional       loss of function
are associated with clinical severity in the mild cognitive impairment (MCI), and dementia stages of Alzheimer disease (AD)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
diabetetype 2 
may serve as a potential target for the treatment of Gestational diabetes mellitus (GDM)
miscelleaneouspain 
ADCYAP1 and its receptors may be promising targets for migraine therapeutics
ANIMAL & CELL MODELS
  • Pacap global knockout mice have decreased fertility and Pacap modulates LH release
  • Pacap Knockout (KO) mice exhibit a Sudden Infant Death Syndrome (SIDS)-like phenotype, with an inability to overcome noxious insults, compression of baseline ventilation, and death in the early post-neonatal period (