Symbol
| ADCYAP1
| contributors: mct/npt - updated : 29-12-2020
|
HGNC name
| adenylate cyclase activating polypeptide 1 (pituitary)
|
HGNC id
| 241
|
Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
constitutional
|  
|  
|  
| gain of function
|
following nerve decompression, and its and its expression was associated with recovery of intraepidermal nerve fibres | constitutional
|  
|  
|  
| loss of function
|
are associated with clinical severity in the mild cognitive impairment (MCI), and dementia stages of Alzheimer disease (AD) | |
Variant & Polymorphism
|
| |
Candidate gene
Marker
Therapy target
|
System | Type | Disorder | Pubmed |
diabete | type 2 | | |
may serve as a potential target for the treatment of Gestational diabetes mellitus (GDM) | miscelleaneous | pain | | |
ADCYAP1 and its receptors may be promising targets for migraine therapeutics |
| | | |
| Pacap global knockout mice have decreased fertility and Pacap modulates LH release | |
Pacap Knockout (KO) mice exhibit a Sudden Infant Death Syndrome (SIDS)-like phenotype, with an inability to overcome noxious insults, compression of baseline ventilation, and death in the early post-neonatal period ( |