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FLASH GENE

Symbol

KIF20A

contributors: - updated : 12-06-2003

HGNC name	kinesin family member 20A
HGNC id	9787

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
text structure	CDE-CHR element in the promoter

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D5S500 - CDC25C - EGR1 - FGF1 - HARS - D5S2119 - D5S402 - D5S406 - qter
Authors	GeneMap (98)

regionally located

in the smallest commonly

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly   thymus       highly Cardiovascular heart       lowly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Lymphoid         Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

cell cycle

cell cycle, M

Text	tissues highly placenta lowly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a motor domain and an ATP catalitic domain,hallmarks of kinesin like proteins,in the N terminus

HOMOLOGY

interspecies

homolog to murine Rab6kifl

Homologene

FAMILY

kinesin like protein kinase family

CATEGORY

motor/contractile , signaling , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	in later stages of mitosis,localized to the spindle mid-zone

basic FUNCTION	acting as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules
	crucial role in late anaphase B and/or cytokinesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	vesicular transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GTP bound forms of RAB6A and RAB6B

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS