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FLASH GENE
Symbol CDC25C contributors: mct - updated : 05-01-2017
HGNC name cell division cycle 25 homolog C (S. pombe)
HGNC id 1727
Location 5q31.2      Physical location : 137.620.958 - 137.667.516
Synonym name
  • mitosis inducer CDC25
  • cdc25 protein phosphatase, non receptor type, form C
  • dual specificity phosphatase Cdc25C
  • phosphotyrosine phosphatase
  • protein phosphatase 1, regulatory subunit 60
    • Synonym symbol(s) CDC25, PPP1R60
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 53.09 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text
  • only two variants full-length described
    • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2115 53.2 473 - 2015 25633196
    14 exons
    11 splicing 1896 45.5 400 - 2015 25633196
    11 exons
    14 - 2304 - 551 - 2015 25633196
    14 - 2308 - 490 - 2015 25633196
    14 - 2187 - 473 - 2015 25633196
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
     tonsils   highly
    Reproductivefemale systemuterus  predominantly
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G2, checkpoint, G2M
    Text expressed predominantly in G2 phase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rhodanese-like motif
  • an intrinsic nuclear export signal
  • an HIV-1 Vpr binding site
  • catalytic C-terminal domain mediating its centrosomal localisation
    • HOMOLOGY
    interspecies homolog to rattus Cdc25c (68.8 pc)
    homolog to murine Cdc25c (71.5 pc)
    Homologene
    FAMILY
  • CDC25 phosphatase family
  • MPI phosphatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm
    text
  • entering in the nucleus to activate the cyclin B/cdk1 complex at G(2)/M transition
  • thought to act at a later stage of mitosis and in the nucleus
  • a fraction localises to centrosomes in a cell cycle-dependent fashion, as of late S phase and throughout G(2) and mitosis
  • is predominantly a nuclear protein in mammalian cells
    • basic FUNCTION
  • acting as a dual specificity (tyr/thr) phosphatase
  • being a regulator of the cell cycle entered into mitosis by dephosphorylating the protein kinase CDC2
  • playing an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes
  • might play an important role in prostate cancer progression and could be used to monitor and predict the aggressiveness of this disease
  • functioning as a dosage-dependent inducer in mitotic control
  • acting as a tyrosine protein phosphatase required for progression of the cell cycle
  • directly dephosphorylating CDC2 and activating its kinase activity
  • forming part of the regulatory circuit controling mitosis entry by binding to PLK1
  • activating CDC2 by dephosphorylation of T14, Y15, 14.3.3 proteins for nuclear export of CDC25C
  • playing a role in the Golgi apparatus
  • dual-specificity phosphatases that coordinate entry into mitosis through activating dephosphorylation of CDKN1A, CCNB1
  • coordinate cell cycle progression through activating dephosphorylation of Cyclin-dependent kinases
  • having an unexpected function at the G(2)/M transition, in dephosphorylation of CDK1
  • with CSC25A and CDC25B, are implicated at G1/S, during S-phase, at G2/M and during mitosis (are implicated at G1/S, during S-phase, at G2/M and during mitosis
  • inactivation or degradation of CDC25 promotes cancer development through accelerated mitotic progression
  • plays an important role in transitions between cell-cycle phases by dephosphorylating and activating CDKs
  • CDC25B and CDC25C play a major role in G2/M progression, whereas CDC25A assists in G1/S transition
    • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV-1 Vpr (producing inactivation of CDC25C phosphatase activity)
  • dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability
  • BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry
  • is a direct transcriptional target of KIF22, and inhibition of KIF22 increased CDC25C expression and cyclin-dependent kinase 1 (CDK1) activity, resulting in delayed mitotic exit
  • during cell division, CDC25C dephosphorylates CDK1 to activate the CDK1-Cyclin B complex, resulting in mitotic entry
  • at the G2/M transition, mitotic activation of CDC25C protein occurs by its dissociation from 14-3-3 proteins along with its phosphorylation at multiple sites within its N-terminal domain
    • cell & other
    REGULATION
    activated by the oncogenic serine/threonine kinase PIM1 (directly phosphorylates and activates the G2/M specific phosphatase CDC25C)
    Other regulated by phosphorylation which by itself is implicated in regulating the subcellular localization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS