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FLASH GENE

Symbol

CDC25C

contributors: mct - updated : 05-01-2017

HGNC name	cell division cycle 25 homolog C (S. pombe)
HGNC id	1727

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31.2      Physical location : 137.620.958 - 137.667.516
Synonym name	mitosis inducer CDC25
	cdc25 protein phosphatase, non receptor type, form C
	dual specificity phosphatase Cdc25C
	phosphotyrosine phosphatase
	protein phosphatase 1, regulatory subunit 60
Synonym symbol(s)	CDC25, PPP1R60
EC.number	3.1.3.48

DNA

TYPE	functioning gene
STRUCTURE	53.09 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	only two variants full-length described

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001790 14 splicing 2115 NP_001781 53.2 473 - 2015 25633196 14 exons NM_022809 11 splicing 1896 NP_073720 45.5 400 - 2015 25633196 11 exons NM_001287583 14 - 2304 NP_001274512 - 551 - 2015 25633196 NM_001318098 14 - 2308 NP_001305027 - 490 - 2015 25633196 NM_001287582 14 - 2187 NP_001274511 - 473 - 2015 25633196

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Lymphoid/Immune lymph node       moderately   tonsils       highly Reproductive female system uterus     predominantly   male system testis     highly Respiratory respiratory tract larynx     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle, G2, checkpoint, G2M

Text	expressed predominantly in G2 phase

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a rhodanese-like motif
	an intrinsic nuclear export signal
	an HIV-1 Vpr binding site
	catalytic C-terminal domain mediating its centrosomal localisation

HOMOLOGY

interspecies	homolog to rattus Cdc25c (68.8 pc)
	homolog to murine Cdc25c (71.5 pc)

Homologene

FAMILY	CDC25 phosphatase family
	MPI phosphatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus,nucleoplasm
text	entering in the nucleus to activate the cyclin B/cdk1 complex at G(2)/M transition
	thought to act at a later stage of mitosis and in the nucleus
	a fraction localises to centrosomes in a cell cycle-dependent fashion, as of late S phase and throughout G(2) and mitosis
	is predominantly a nuclear protein in mammalian cells

basic FUNCTION	acting as a dual specificity (tyr/thr) phosphatase
	being a regulator of the cell cycle entered into mitosis by dephosphorylating the protein kinase CDC2
	playing an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes
	might play an important role in prostate cancer progression and could be used to monitor and predict the aggressiveness of this disease
	functioning as a dosage-dependent inducer in mitotic control
	acting as a tyrosine protein phosphatase required for progression of the cell cycle
	directly dephosphorylating CDC2 and activating its kinase activity
	forming part of the regulatory circuit controling mitosis entry by binding to PLK1
	activating CDC2 by dephosphorylation of T14, Y15, 14.3.3 proteins for nuclear export of CDC25C
	playing a role in the Golgi apparatus
	dual-specificity phosphatases that coordinate entry into mitosis through activating dephosphorylation of CDKN1A, CCNB1
	coordinate cell cycle progression through activating dephosphorylation of Cyclin-dependent kinases
	having an unexpected function at the G(2)/M transition, in dephosphorylation of CDK1
	with CSC25A and CDC25B, are implicated at G1/S, during S-phase, at G2/M and during mitosis (are implicated at G1/S, during S-phase, at G2/M and during mitosis
	inactivation or degradation of CDC25 promotes cancer development through accelerated mitotic progression
	plays an important role in transitions between cell-cycle phases by dephosphorylating and activating CDKs
	CDC25B and CDC25C play a major role in G2/M progression, whereas CDC25A assists in G1/S transition

CELLULAR PROCESS	cell cycle, division, mitosis
	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with HIV-1 Vpr (producing inactivation of CDC25C phosphatase activity)
	dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability
	BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry
	is a direct transcriptional target of KIF22, and inhibition of KIF22 increased CDC25C expression and cyclin-dependent kinase 1 (CDK1) activity, resulting in delayed mitotic exit
	during cell division, CDC25C dephosphorylates CDK1 to activate the CDK1-Cyclin B complex, resulting in mitotic entry
	at the G2/M transition, mitotic activation of CDC25C protein occurs by its dissociation from 14-3-3 proteins along with its phosphorylation at multiple sites within its N-terminal domain

cell & other

REGULATION

activated by

the oncogenic serine/threonine kinase PIM1 (directly phosphorylates and activates the G2/M specific phosphatase CDC25C)

Other

regulated by phosphorylation which by itself is implicated in regulating the subcellular localization

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS