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Symbol CDC25C contributors: mct - updated : 05-01-2017
HGNC name cell division cycle 25 homolog C (S. pombe)
HGNC id 1727
Location 5q31.2      Physical location : 137.620.958 - 137.667.516
Synonym name
  • mitosis inducer CDC25
  • cdc25 protein phosphatase, non receptor type, form C
  • dual specificity phosphatase Cdc25C
  • phosphotyrosine phosphatase
  • protein phosphatase 1, regulatory subunit 60
  • Synonym symbol(s) CDC25, PPP1R60
    TYPE functioning gene
    STRUCTURE 53.09 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SPOCK 5q31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) KLHL3 5q31 kelch-like 3 (Drosophila) HNRPA0 5q31 heterogeneous nuclear ribonucleoprotein A0 NPY6R 5q31 neuropeptide Y receptor Y6 (pseudogene) TTID 5q31 titin immunoglobulin domain protein (myotilin) PKD2L2 5q31 polycystic kidney disease 2-like 2 C5orf5 5q31 chromosome 5 open reading frame 5 WNT8A 5q31 wingless-type MMTV integration site family, member 8A NME5 5q31.1 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) BRD8 5q31.2 bromodomain containing 8 KIF20A 5q31 kinesin family member 20A CDC23 5q31.1 CDC23 (cell division cycle 23, yeast, homolog) GFRA3 5q31.1-q31.3 GDNF family receptor alpha 3 CDC25C 5q31 cell division cycle 25C C5orf6 5q31 chromosome 5 open reading frame 6 C5orf7 5q31 chromosome 5 open reading frame 7 LOC51308 5q31 SGC32445 protein EGR1 5q31.1 early growth response 1 ETF1 5q31.1 eukaryotic translation termination factor 1 HSPA9B 5q31.1 heat shock 70kDa protein 9B (mortalin-2) LOC391836 5 similar to ribosomal protein L10a CTNNA1 5q31.1 catenin (cadherin-associated protein), alpha 1, 102kDa LRRTM2 5q31.3 catenin (cadherin-associated protein), alpha 1, 102kDa SIL1 5q31 endoplasmic reticulum chaperone SIL1, homolog of yeast MATR3 5q31.1-q31.3 matrin 3 PAIP2 5q31.1-q31.3 matrin 3 SLC23A1 20p13 solute carrier family 23 (nucleobase transporters), member 1 PACAP 5q23-5q31 proapoptotic caspase adaptor protein LOC389333 5 LOC389333 LOC389334 5 LOC389334 LOC202051 5q31.3 hypothetical protein LOC202051 MGC29463 5q31.3 hypothetical protein MGC29463
    TRANSCRIPTS type messenger
  • only two variants full-length described
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2115 53.2 473 - 2015 25633196
    14 exons
    11 splicing 1896 45.5 400 - 2015 25633196
    11 exons
    14 - 2304 - 551 - 2015 25633196
    14 - 2308 - 490 - 2015 25633196
    14 - 2187 - 473 - 2015 25633196
    Type widely
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
     tonsils   highly
    Reproductivefemale systemuterus  predominantly
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    at STAGE
    cell cycle     cell cycle, G2, checkpoint, G2M
    Text expressed predominantly in G2 phase
  • a rhodanese-like motif
  • an intrinsic nuclear export signal
  • an HIV-1 Vpr binding site
  • catalytic C-terminal domain mediating its centrosomal localisation
    interspecies homolog to rattus Cdc25c (68.8 pc)
    homolog to murine Cdc25c (71.5 pc)
  • CDC25 phosphatase family
  • MPI phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
  • entering in the nucleus to activate the cyclin B/cdk1 complex at G(2)/M transition
  • thought to act at a later stage of mitosis and in the nucleus
  • a fraction localises to centrosomes in a cell cycle-dependent fashion, as of late S phase and throughout G(2) and mitosis
  • is predominantly a nuclear protein in mammalian cells
  • basic FUNCTION
  • acting as a dual specificity (tyr/thr) phosphatase
  • being a regulator of the cell cycle entered into mitosis by dephosphorylating the protein kinase CDC2
  • playing an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes
  • might play an important role in prostate cancer progression and could be used to monitor and predict the aggressiveness of this disease
  • functioning as a dosage-dependent inducer in mitotic control
  • acting as a tyrosine protein phosphatase required for progression of the cell cycle
  • directly dephosphorylating CDC2 and activating its kinase activity
  • forming part of the regulatory circuit controling mitosis entry by binding to PLK1
  • activating CDC2 by dephosphorylation of T14, Y15, 14.3.3 proteins for nuclear export of CDC25C
  • playing a role in the Golgi apparatus
  • dual-specificity phosphatases that coordinate entry into mitosis through activating dephosphorylation of CDKN1A, CCNB1
  • coordinate cell cycle progression through activating dephosphorylation of Cyclin-dependent kinases
  • having an unexpected function at the G(2)/M transition, in dephosphorylation of CDK1
  • with CSC25A and CDC25B, are implicated at G1/S, during S-phase, at G2/M and during mitosis (are implicated at G1/S, during S-phase, at G2/M and during mitosis
  • inactivation or degradation of CDC25 promotes cancer development through accelerated mitotic progression
  • plays an important role in transitions between cell-cycle phases by dephosphorylating and activating CDKs
  • CDC25B and CDC25C play a major role in G2/M progression, whereas CDC25A assists in G1/S transition
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    a component
    small molecule
  • interacting with HIV-1 Vpr (producing inactivation of CDC25C phosphatase activity)
  • dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability
  • BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry
  • is a direct transcriptional target of KIF22, and inhibition of KIF22 increased CDC25C expression and cyclin-dependent kinase 1 (CDK1) activity, resulting in delayed mitotic exit
  • during cell division, CDC25C dephosphorylates CDK1 to activate the CDK1-Cyclin B complex, resulting in mitotic entry
  • at the G2/M transition, mitotic activation of CDC25C protein occurs by its dissociation from 14-3-3 proteins along with its phosphorylation at multiple sites within its N-terminal domain
  • cell & other
    activated by the oncogenic serine/threonine kinase PIM1 (directly phosphorylates and activates the G2/M specific phosphatase CDC25C)
    Other regulated by phosphorylation which by itself is implicated in regulating the subcellular localization
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Variant & Polymorphism
    Candidate gene
    Therapy target