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FLASH GENE
Symbol CDC25C contributors: mct - updated : 15-02-2011
HGNC name cell division cycle 25 homolog C (S. pombe)
HGNC id 1727
Location 5q31      Physical location : 137.620.958 - 137.667.516
Synonym name
  • mitosis inducer CDC25
  • cdc25 protein phosphatase, non receptor type, form C
  • dual specificity phosphatase Cdc25C
  • phosphotyrosine phosphatase
  • Synonym symbol(s) CDC25
    EC.number 3.1.3.48
    DNA
    TYPE functioning gene
    STRUCTURE 46.56 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    SPOCK 5q31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) KLHL3 5q31 kelch-like 3 (Drosophila) HNRPA0 5q31 heterogeneous nuclear ribonucleoprotein A0 NPY6R 5q31 neuropeptide Y receptor Y6 (pseudogene) TTID 5q31 titin immunoglobulin domain protein (myotilin) PKD2L2 5q31 polycystic kidney disease 2-like 2 C5orf5 5q31 chromosome 5 open reading frame 5 WNT8A 5q31 wingless-type MMTV integration site family, member 8A NME5 5q31.1 non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) BRD8 5q31.2 bromodomain containing 8 KIF20A 5q31 kinesin family member 20A CDC23 5q31.1 CDC23 (cell division cycle 23, yeast, homolog) GFRA3 5q31.1-q31.3 GDNF family receptor alpha 3 CDC25C 5q31 cell division cycle 25C C5orf6 5q31 chromosome 5 open reading frame 6 C5orf7 5q31 chromosome 5 open reading frame 7 LOC51308 5q31 SGC32445 protein EGR1 5q31.1 early growth response 1 ETF1 5q31.1 eukaryotic translation termination factor 1 HSPA9B 5q31.1 heat shock 70kDa protein 9B (mortalin-2) LOC391836 5 similar to ribosomal protein L10a CTNNA1 5q31.1 catenin (cadherin-associated protein), alpha 1, 102kDa LRRTM2 5q31.3 catenin (cadherin-associated protein), alpha 1, 102kDa SIL1 5q31 endoplasmic reticulum chaperone SIL1, homolog of yeast MATR3 5q31.1-q31.3 matrin 3 PAIP2 5q31.1-q31.3 matrin 3 SLC23A1 20p13 solute carrier family 23 (nucleobase transporters), member 1 PACAP 5q23-5q31 proapoptotic caspase adaptor protein LOC389333 5 LOC389333 LOC389334 5 LOC389334 LOC202051 5q31.3 hypothetical protein LOC202051 MGC29463 5q31.3 hypothetical protein MGC29463
    RNA
    TRANSCRIPTS type messenger
    text
  • only two variants full-length described
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 2115 53.2 473 - 1990 2195549
    14 exons
    11 splicing 1896 45.5 400 - 1990 2195549
    11 exons
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
     tonsils   highly
    Reproductivefemale systemuterus  predominantly
     male systemtestis  highly
    Respiratoryrespiratory tractlarynx  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, G2, checkpoint, G2M
    Text expressed predominantly in G2 phase
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a rhodanese-like motif
  • an intrinsic nuclear export signal
  • an HIV-1 Vpr binding site
  • catalytic C-terminal domain mediating its centrosomal localisation
  • HOMOLOGY
    interspecies homolog to rattus Cdc25c (68.8 pc)
    homolog to murine Cdc25c (71.5 pc)
    Homologene
    FAMILY
  • CDC25 phosphatase family
  • MPI phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • entering in the nucleus to activate the cyclin B/cdk1 complex at G(2)/M transition
  • thought to act at a later stage of mitosis and in the nucleus
  • a fraction localises to centrosomes in a cell cycle-dependent fashion, as of late S phase and throughout G(2) and mitosis
  • basic FUNCTION
  • acting as a dual specificity (tyr/thr) phosphatase
  • being a regulator of the cell cycle entered into mitosis by dephosphorylating the protein kinase CDC2
  • playing an important role in the G2-M transition by activating Cdc2/Cyclin B1 complexes
  • might play an important role in prostate cancer progression and could be used to monitor and predict the aggressiveness of this disease
  • functioning as a dosage-dependent inducer in mitotic control
  • acting as a tyrosine protein phosphatase required for progression of the cell cycle
  • directly dephosphorylating CDC2 and activating its kinase activity
  • forming part of the regulatory circuit controling mitosis entry by binding to PLK1
  • activating CDC2 by dephosphorylation of T14, Y15, 14.3.3 proteins for nuclear export of CDC25C
  • playing a role in the Golgi apparatus
  • dual-specificity phosphatases that coordinate entry into mitosis through activating dephosphorylation of CDKN1A, CCNB1
  • coordinate cell cycle progression through activating dephosphorylation of Cyclin-dependent kinases
  • having an unexpected function at the G(2)/M transition, in dephosphorylation of CDK1
  • with CSC25A and CDC25B, are implicated at G1/S, during S-phase, at G2/M and during mitosis (are implicated at G1/S, during S-phase, at G2/M and during mitosis
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with HIV-1 Vpr (producing inactivation of CDC25C phosphatase activity)
  • dysfunctional telomeres promote ATM/ATR-dependent degradation of CDC25C phosphatase to block mitotic entry, thereby preventing telomere dysfunction-driven genomic instability
  • BRCA1-dependent degradation of cyclin B and CDC25C is reversed by proteasome inhibitors and is enhanced following DNA damage, which may represent a possible mechanism to prevent cyclin B and CDC25C accumulation, a requirement for mitotic entry
  • cell & other
    REGULATION
    activated by the oncogenic serine/threonine kinase PIM1 (directly phosphorylates and activates the G2/M specific phosphatase CDC25C)
    Other regulated by phosphorylation which by itself is implicated in regulating the subcellular localization
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS