| basic FUNCTION
| involved in cell proliferation, macrophage differentiation |
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synaptic activation and long term potentiation |
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key mediator of inflammation and apoptosis in vascular cells |
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activating the transcription of target genes whose products are required for mitogenesis and differentiation |
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involved in TOPBP1 regulation |
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role in regulating hepatocellular mitotic progression through the spindle assembly checkpoint during liver regeneration ( |
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has an essential role in learning and memory processing that appears to be partly distinct from the role of EGR3 |
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functions in cell growth, development, and stress responses in many tissues, and in regulating homeostasis of hematopoietic stem cells (HSCs) |
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may commands a genetic program that coordinates stem cell division and migration to maintain appropriate HSC number and function |
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negative role in adipocyte differentiation |
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EGR1, EGR2, EGR3, are essential for conversion of the mitogenic signal of epidermal growth factor into a proliferative response |
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involved in regulating homeostasis of hematopoietic stem cells (HSC) by coordinating proliferation and migration |
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target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons |
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central regulator of early inflammatory and immune processes by rapidly regulating the transcription of a wide array of downstream effector genes |
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essential for MMP9 transcription in response to TNFalpha within the tumor microenvironment |
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central role of EGR1, in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma |
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connection between EGR1 and PTEN may be a common mechanism underlying the apoptotic response of many human tumors to radiation and chemotherapy |
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central role of the transcription factor EGR1 in synovial sarcoma cell survival and HDAC inhibitor-induced apoptotic effects on synovial sarcoma |
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EGR1, EGR2 are novel DNA-binding proteins involved in vertebrate tendon differentiation by regulating type I collagen production |
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EGR1-promoted GGPPS1 transcription increased RAS prenylation and caused Erk1/2 activation |
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participates in the development of insulin resistance in adipocytes |
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transactivates Bim gene expression to mediate apoptosis of rat cerebellar granule neurons ( |
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sufficient and necessary for neuronal apoptosis ( |
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activates CDK5 to promote phosphorylation of MAPT and inactivates PP1 via phosphorylation |
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regulator of MAPT phosphorylation |
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modulator of the cholesterol biosynthetic gene family in liver |
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regulates angiogenic and fibrogenic factor production in mesenchymal stem cells |
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nuclear transcription factor, which is considered to be the critical initiating factor of the processes of ascular smooth muscle cells (VSMCs) proliferation and migration |
