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FLASH GENE

Symbol

KIF20A

contributors: - updated : 12-06-2003

HGNC name	kinesin family member 20A
HGNC id	9787

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	5q31      Physical location : 137.514.416 - 137.523.403
Synonym name	RAB6 interacting, kinesin-like (rabkinesin 6)
Synonym symbol(s)	RB6K, RAB6KIFL

DNA

TYPE	functioning gene
STRUCTURE	8.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   HRE
text structure	CDE-CHR element in the promoter

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D5S500 - CDC25C - EGR1 - FGF1 - HARS - D5S2119 - D5S402 - D5S406 - qter
Authors	GeneMap (98)

regionally located

in the smallest commonly

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       lowly   thymus       highly Cardiovascular heart       lowly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Connective bone       Lymphoid         Muscular striatum cardiac

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

cell cycle

cell cycle, M

Text	tissues highly placenta lowly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a motor domain and an ATP catalitic domain,hallmarks of kinesin like proteins,in the N terminus

HOMOLOGY

interspecies

homolog to murine Rab6kifl

Homologene

FAMILY

kinesin like protein kinase family

CATEGORY

motor/contractile , signaling , transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	in later stages of mitosis,localized to the spindle mid-zone

basic FUNCTION	acting as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules
	crucial role in late anaphase B and/or cytokinesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	vesicular transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

GTP bound forms of RAB6A and RAB6B

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS