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FLASH GENE
Symbol CCR9 contributors: mct - updated : 12-07-2007
HGNC name chemokine (C-C motif) receptor 9
HGNC id 1610
Location 3p21.3      Physical location : 45.927.995 - 45.944.667
Synonym symbol(s) GPR9-6, GPR6966, GPR28, CDw199, GPR-9-6
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 16.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - CCR4 - D3S1768 - D3S1561 - CCR8 - CX3CR1 - D3S2354 - CCBP2 - CCR9 - CCR3 - CCR1 - XCR1 - CCR2 - CCR5 - D3S1078 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2544 41.9 369 - Yu, 2000
  • 3 exons
    • - splicing 2462 40.6 357 - Yu, 2000
  • 2 exons
    		•
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunelymph node   lowly
     spleen   lowly
     thymus   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM) receptor
    conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Ccr9 (86.5 pc)
    homolog to murine Ccr9 (85.6 pc)
    Homologene
    FAMILY
  • G protein coupled receptor superfamily (family 1)
  • beta chemokine receptor family
    • CATEGORY immunity/defense , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting as a specific receptor for chemokine SCYA25/TECK
  • transducing subsequently a signal by increasing the intracellular calcium ions level
  • acting as a alternative coreceptor with CD4 for HIV-1 infection
  • acting as a rhodopsin-like receptor
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by TLR2 ligands that induce CCR9 and CCR10 expression by circulating B cells and increased chemotaxis to cognate chemokines CCL25 and CCL28
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS