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FLASH GENE

Symbol

ZNF81

contributors: mct - updated : 05-10-2017

HGNC name	zinc finger protein 81 (HFZ20)
HGNC id	13156

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered with ZNF41, ZNF21, ZNF157
STRUCTURE	88.76 kb     6 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - UBE1 - TIMP1 - SYN1 - PFC - DXS426 - ELK1 - ZNF81 - DXS6849 - ZNF21 - TBC1D25 - WAS ,DXS6940 - GATA1 ,DXS1126 - DXS1240 - TFE3 ,SYP - DXS255 - cen
Authors	Bech-Hansen (93), Knight (93), Kwan (95)
Text	see ZNF157

regionally located

close to a translocation breakpoint at OATL1

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007137 5 - 7859 NP_009068 - 661 - 2004 15121780

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain         Reproductive female system ovary       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve zinc finger motifs, C2H2 type, Krüppel-like at the C terminus
	a Kruppel-associated box (KRAB) domain

conjugated

MetalloP

HOMOLOGY

intraspecies

homolog to ZNF41

Homologene

FAMILY

zinc finger protein family, C2H2 type, Krüppel-like

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION

is thought to mediate gene silencing through the interaction with both heterochromatin protein HP1 and histon modifying proteins (histon deacetylases and methyltransferases)

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MRX45

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS