| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
|
in esophageal carcinoma (mild overexpression in moderate dysplasia) and breast carcinoma |
| tumoral
|
|
| --over
|
|
positive correlation was shown for its overexpression and tumor stage and lymph node metastasis, in clear cell renal cell carcinomas  |
| tumoral
|
|
| --over
|
|
|
of KIT, TP53, and MKI67 reflects tumor grade and predicts survival in neuroendocrine carcinomas, but fail as prognostic markers in the subset of small cell lung cancer patients |
| tumoral
|
|
| --over
|
|
|
strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis in melanoma ( |
| tumoral
|
|
| --over
|
|
|
endothelial proliferation assessed on MKI67 combined with the lack of CD105 expression is often associated with invasive cervical carcinoma ( |
| tumoral
|
|
| --low
|
|
|
significant association between MKI67 and survival was shown regardless of primary tumor proliferation in advanced breast cancer |
