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FLASH GENE

Symbol

BMP3

contributors: mct - updated : 02-02-2008

HGNC name	bone morphogenetic protein 3
HGNC id	1070

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.57 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001201 3 - 5734 NP_001192 - 472 - 2007 17924656

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         pharynx         Respiratory lung         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	fetal eye, fetal lung

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

TGF-beta-like domain

mono polymer

homomer , dimer

isoforms

Precursor

cleaved at a consensus Arg-X-XArg to yield a C ter mature dimer

HOMOLOGY

interspecies

homolog to Drosophila decapentaplegic-Vg,DVR family

Homologene

FAMILY

TGFB superfamily

CATEGORY

signaling growth factor

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION

negative regulator of bone density (antagonist of endogenous BMPs)

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

text	cartilage and bone formation

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	BMP2 (antagonist)
	interacting with TGFB1 (BMP3 stimulates mesenchymal stem cell (MSC) proliferation via the TGF-beta/activin signaling pathway, and both are implicated in regulating MSC proliferation) )

cell & other

REGULATION

activated by

cleaved by subtilisin-like convertases

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in malignant schwannoma tumoral     --low   in colorectal carcinoma, by promoter hypermethylation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	attractive target for the future development of molecular blood and/or stool screening tests for the early detection of lesions with neoplastic potential

ANIMAL & CELL MODELS

mouse Bmp3-/-have as much trabecular bone as wild type littermates