| basic FUNCTION
| serine protease, releasing the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen |
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as other KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI  |
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critical role in arterial function |
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is also involved in the control of ionic transport in the renal tubule, an action that may not be kinin-mediated |
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kinin-forming serine protease synthesized in many organs including arteries and kidney |
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KLK9 and KLK10, once activated, are unlikely to participate in further pro-KLK activation pathways, although similar to KLK1 they may activate other bioactive peptides |
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tissue KLK1 is essential for invasive capacity of circulating proangiogenic cells |
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is a tissue enzyme responsible for kinin release in inflammatory cascade |
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plays likely an antihypertensive role in hyperaldosteronism |
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KLK1/kinin system plays a role in the effects of radiation on cardiac function and recruitment of inflammatory cells, at least in part by altering Erk1/2 signaling |
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KLK1 and TIMP1 are important in inhibiting vascular smooth muscle cell (VSMC) proliferation and improving vascular remodeling, respectively |
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initiated autophagy while maintaining normal autophagic flux |
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secretion of KLK1, the kinin-forming enzyme, may perpetuate formation of kinin in the inflammatory milieu by hydrolyzing extravasated kininogens present in tissue edema |
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KLK1 is responsible for the generation of kinins (bradykinin and kallidin), which promote local vasodilation and long-term vascularization |
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KLK1 intervenes early in the antiviral defense modulating the severity of influenza infection |
