| basic FUNCTION
| transcriptional repressor of smad target gene |
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playing a role in the patterning of neural crest-derived cells and of the central nervous system but also in the development of midline structures |
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down regulating E-cadherin transcription |
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during epithelial dedifferentiation, represses in a coordinated manner the transcription of genes coding for junctional proteins contributing to the dedifferentiated state |
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may contribute to tumor progression by protecting cancer cells from apoptosis including DNA-damage-dependent apoptotic pathways induced by activated oncogenes  |
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modulator of the epithelial-mesenchymal transition, and strongly downregulated by MIR221 |
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played an essential role in the GH1-dependent decrease in CDH1 expression |
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essential for transducing the effect of GH1 on CDH1 expression in the glomerular podocyte |
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GH1-dependent increase in ZEB2 plays a role in epithelial-mesenchymal transition in the podocyte and provides a cellular and molecular basis for the role of GH1 in the pathogenesis of diabetic nephropathy |
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controls the transduction properties of heat-sensitive primary sensory neurons and thus thermal pain sensitivity in a novel manner via coordinated changes in DRG-neuron voltage-gated ion channels |
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regulates both early and late mast cell responses |
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transcription factor ZEB2 controls the expression of molecules thereby regulating signaling in mast cells |
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ZEB2, although undetectable in adult Schwann cells, has a latent function throughout life. |
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balance between ZEB2 and KLF4 protein levels is important for the modulation of CDH1 expression |
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is involved in the development of primary sensory dorsal root ganglia (DRG) neurons |
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plays a major role in reprogramming the lens vesicle away from a surface ectoderm cell fate towards that necessary for the development of a transparent lens, demonstrating that ZEB2 regulates distinctly different sets of genes in different cellular contexts |
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its expression in the epidermis leads to hyperproliferation due to the combined downregulation of different tight junction proteins compromising the epidermal barrier |
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transcription factor ZEB2 is Required to maintain the tissue-specific identities of macrophages |
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DNA-binding transcription factor, which is mainly involved in epithelial-to-mesenchymal transition (EMT) |
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is a novel myogenic regulator and a possible target for improving skeletal muscle regeneration |
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endothelial ZEB2 preserves liver angioarchitecture and protects against liver fibrosis |
