| 1 | FOXD1, ZEB2
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| ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.
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| Kumar S, Fan X, Rasouly HM, Sharma R, Salant DJ, Lu W.
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| JCI Insight. Jan 10;8(1):e158418. doi: 10.1172/jci.insight.158418. 2023
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| 2 | ZEB2
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| Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis.
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| de Haan W, Dheedene W, Apelt K, Décombas-Deschamps S, Vinckier S, Verhulst S, Conidi A, Deffieux T, Staring MW, Vandervoort P, Caluwé E, Lox M, Mannaerts I, Takagi T, Jaekers J, Berx G, Haigh J, Topal B, Zwijsen A, Higashi Y, van Grunsven LA, van IJcken WFJ, Mulugeta E, Tanter M, Lebrin FPG, Huylebroeck D, Luttun A.
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| Cardiovasc Res. Mar 25;118(5):1262-1275. doi: 10.1093/cvr/cvab148. 2022
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| 3 | MOWS, ZEB2
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| ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises.
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| Birkhoff JC, Huylebroeck D, Conidi A.
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| Genes (Basel). Jul 3;12(7):1037. doi: 10.3390/genes12071037. 2021
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| 4 | MDM2, ZEB2
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| ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage.
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| Guo Q, Xie M, Guo M, Yan F, Li L, Liu R.
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| Cell Cycle. Sep;20(17):1692-1707. doi: 10.1080/15384101.2021.1959702. Epub 2021 Aug 2. 2021
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| 5 | ZEB2
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| Zeb2 Regulates Myogenic Differentiation in Pluripotent Stem Cells.
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| Di Filippo ES, Costamagna D, Giacomazzi G, Cortés-Calabuig Á, Stryjewska A, Huylebroeck D, Fulle S, Sampaolesi M.
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| Int J Mol Sci. Apr 5;21(7):2525. doi: 10.3390/ijms21072525. 2020
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| 6 | MOWS, ZEB2
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| Role of Zeb2/Sip1 in neuronal development.
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| Epifanova E, Babaev A, Newman AG, Tarabykin V.
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| Brain Res. Feb 15;1705:24-31. doi: 10.1016/j.brainres.2018.09.034. Epub 2018 Sep 25. 2019
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| 7 | ZEB2
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| The crucial role of ZEB2: From development to epithelial-to-mesenchymal transition and cancer complexity.
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| Fardi M, Alivand M, Baradaran B, Farshdousti Hagh M, Solali S.
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| J Cell Physiol. Sep;234(9):14783-14799. doi: 10.1002/jcp.28277. Epub 2019 Feb 17. 2019
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| 8 | ZEB2
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| The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
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| Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.
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| Immunity Aug 21;49(2):312-325.e5. doi: 10.1016/j.immuni.2018.07.004. Epub 2018 Jul 31. 2018
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| 9 | ZEB2
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| Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair.
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| Quintes S, Brinkmann BG, Ebert M, Fröb F, Kungl T, Arlt FA, Tarabykin V, Huylebroeck D, Meijer D, Suter U, Wegner M, Sereda MW, Nave KA.
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| Nat Neurosci. Aug;19(8):1050-1059. doi: 10.1038/nn.4321. Epub 2016 Jun 13. 2016
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| 10 | SNAI1, SNAI2, VANGL1, ZEB1, ZEB2
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| KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers.
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| Lee KH, Ahn EJ, Oh SJ, Kim O, Joo YE, Bae JA, Yoon S, Ryu HH, Jung S, Kim KK, Lee JH, Moon KS.
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| Oncotarget 6(5):3240-53.
2015
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| 11 | NIN, ZEB2
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| Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.
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| Srivatsa S, Parthasarathy S, Molnár Z, Tarabykin V.
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| Neuron 85(5):998-1012. doi: 10.1016/j.neuron.2015.01.018.
2015
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| 12 | GADD45G, ZEB2
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| SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells.
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| Xu G, Zhang L, Ma A, Qian Y, Ding Q, Liu Y, Wang B, Yang Z, Liu Y.
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| Oncotarget 6(32):33636-47. doi: 10.18632/oncotarget.5602.
2015
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| 13 | ZEB2
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| ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins.
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| Tatari MN, De Craene B, Soen B, Taminau J, Vermassen P, Goossens S, Haigh K, Cazzola S, Lambert J, Huylebroeck D, Haigh JJ, Berx G.
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| Cell Mol Life Sci 71(18):3599-609. doi: 10.1007/s00018-014-1589-0. Epub 2014 Feb 27.
2014
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| 14 | ZEB2
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| SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse.
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| Nishizaki Y, Takagi T, Matsui F, Higashi Y.
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| Genesis 52(1):56-67. doi: 10.1002/dvg.22726. Epub 2013 Dec 5.
2014
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| 15 | ZEB2
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| Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.
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| Manthey AL, Lachke SA, FitzGerald PG, Mason RW, Scheiblin DA, McDonald JH, Duncan MK.
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| Mech Dev 131:86-110. doi: 10.1016/j.mod.2013.09.005. Epub 2013 Oct 23.
2014
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| 16 | ZEB2
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| Smad-interacting protein 1 affects acute and tonic, but not chronic pain.
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| Pradier B, Jeub M, Markert A, Mauer D, Tolksdorf K, Van de Putte T, Seuntjens E, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Huylebroeck D, Beck H, Zimmer A, Rácz I.
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| Eur J Pain 18(2):249-57. doi: 10.1002/j.1532-2149.2013.00366.x. Epub 2013 Jul 17.
2014
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| 17 | NTF3, ZEB2
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| Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling.
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| Parthasarathy S, Srivatsa S, Nityanandam A, Tarabykin V.
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| Development 141(17):3324-30. doi: 10.1242/dev.114173. Epub 2014 Aug 1.
2014
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| 18 | CDH1, KLF4, ZEB2
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| Interplay between KLF4 and ZEB2/SIP1 in the regulation of E-cadherin expression.
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| Koopmansch B, Berx G, Foidart JM, Gilles C, Winkler R.
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| Biochem Biophys Res Commun 431(4):652-7. doi: 10.1016/j.bbrc.2013.01.070. Epub 2013 Jan 29.
2013
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| 19 | MOWS, ZEB2
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| ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome.
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| Ghoumid J, Drevillon L, Alavi-Naini SM, Bondurand N, Rio M, Briand-Suleau A, Nasser M, Goodwin L, Raymond P, Yanicostas C, Goossens M, Lyonnet S, Mowat D, Amiel J, Soussi-Yanicostas N, Giurgea I.
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| Hum Mol Genet 22(13):2652-61. doi: 10.1093/hmg/ddt114. Epub 2013 Mar 5.
2013
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| 20 | ZEB2
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| ZEB2 mediates multiple pathways regulating cell proliferation, migration, invasion, and apoptosis in glioma.
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| Qi S, Song Y, Peng Y, Wang H, Long H, Yu X, Li Z, Fang L, Wu A, Luo W, Zhen Y, Zhou Y, Chen Y, Mai C, Liu Z, Fang W.
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| PLoS One 7(6):e38842. doi: 10.1371/journal.pone.0038842. Epub 2012 Jun 26.
2012
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| 21 | ZEB2
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| The transcription factor Zeb2 regulates signaling in mast cells.
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| Barbu EA, Zhang J, Berenstein EH, Groves JR, Parks LM, Siraganian RP.
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| J Immunol 188(12):6278-86. doi: 10.4049/jimmunol.1102660. Epub 2012 May 4.
2012
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| 22 | MOWS, ZEB2
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| A novel long-range enhancer regulates postnatal expression of Zeb2: implications for Mowat-Wilson syndrome phenotypes.
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| El-Kasti MM, Wells T, Carter DA.
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| Hum Mol Genet 21(26):5429-42. doi: 10.1093/hmg/dds389. Epub 2012 Sep 21.
2012
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| 23 | ZEB2
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| The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability.
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| Jeub M, Emrich M, Pradier B, Taha O, Gailus-Durner V, Fuchs H, de Angelis MH, Huylebroeck D, Zimmer A, Beck H, Racz I.
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| Pain 152(10):2384-98. doi: 10.1016/j.pain.2011.07.006. Epub 2011 Aug 20.
2011
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| 24 | MEOX2, MIR221, ZEB2
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| Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221.
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| Chen Y, Banda M, Speyer CL, Smith JS, Rabson AB, Gorski DH.
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| Mol Cell Biol 30(15):3902-13. Epub 2010 Jun 1. 2010
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| 25 | CDH1, CDH3, GH1, ZEB2
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| Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy.
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| Kumar PA, Kotlyarevska K, Dejkhmaron P, Reddy GR, Lu C, Bhojani MS, Menon RK.
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| J Biol Chem 285(41):31148-56. Epub 2010 Aug 3.
2010
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| 26 | MOWS, ZEB2
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| Mowat-Wilson syndrome: facial phenotype changing with age: study of 19 Italian patients and review of the literature.
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| Garavelli L, Zollino M, Mainardi PC, Gurrieri F, Rivieri F, Soli F, Verri R, Albertini E, Favaron E, Zignani M, Orteschi D, Bianchi P, Faravelli F, Forzano F, Seri M, Wischmeijer A, Turchetti D, Pompilii E, Gnoli M, Cocchi G, Mazzanti L, Bergamaschi R, De Brasi D, Sperandeo MP, Mari F, Uliana V, Mostardini R, Cecconi M, Grasso M, Sassi S, Sebastio G, Renieri A, Silengo M, Bernasconi S, Wakamatsu N, Neri G.
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| Am J Med Genet A 149A(3):417-26. Review.
2009
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| 27 | ZEB1, ZEB2
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| SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.
|
| Sayan AE, Griffiths TR, Pal R, Browne GJ, Ruddick A, Yagci T, Edwards R, Mayer NJ, Qazi H, Goyal S, Fernandez S, Straatman K, Jones GD, Bowman KJ, Colquhoun A, Mellon JK, Kriajevska M, Tulchinsky E.
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| Proc Natl Acad Sci U S A 106(35):14884-9. Epub 2009 Aug 17.PMID: 19706487 2009
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| 28 | ZEB2
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| Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex.
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| Verstappen G, van Grunsven LA, Michiels C, Van de Putte T, Souopgui J, Van Damme J, Bellefroid E, Vandekerckhove J, Huylebroeck D.
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| Hum Mol Genet 17(8):1175-83. Epub 2008 Jan 8. 2008
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| 29 | MOWS, ZEB2
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| Mowat-Wilson syndrome with craniosynostosis: a case report.
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| Adam MP, Justice AN, Bean LJ, Fernhoff PM.
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| Am J Med Genet A 146A(2):245-6. No abstract available.
2008
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| 30 | MOWS, ZEB2
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| Recurrence of Mowat-Wilson syndrome in siblings with a novel mutation in the ZEB2 gene.
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| Cecconi M, Forzano F, Garavelli L, Pantaleoni C, Grasso M, Dagna Bricarelli F, Perroni L, Di Maria E, Faravelli F.
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| Am J Med Genet A 146A(23):3095-9. No abstract available.
2008
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| 31 | ZEB2, MOWS
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| ZFHX1B mutations in patients with Mowat-Wilson syndrome.
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| Dastot-Le Moal F, Wilson M, Mowat D, Collot N, Niel F, Goossens M.
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| Hum Mutat 28(4):313-321 [Epub ahead of print] 2007
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| 32 | MOWS, ZEB2
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| A 6Mb deletion in band 2q22 due to a complex chromosome rearrangement associated with severe psychomotor retardation, microcephaly and distinctive dysmorphic facial features.
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| Hoffer MJ, Hilhorst-Hofstee Y, Knijnenburg J, Hansson KB, Engelberts AC, Laan LA, Bakker E, Rosenberg C.
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| Eur J Med Genet 50(2):149-54. Epub 2006 Dec 8. 2007
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| 33 | ZEB2, MOWS
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| Atypical ZFHX1B mutation associated with a mild Mowat-Wilson syndrome phenotype.
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| Zweier C, Horn D, Kraus C, Rauch A.
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| Am J Med Genet A 140(8):869-72. 2006
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| 34 | ZEB2, MOWS
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| A missense mutation in the ZFHX1B gene associated with an atypical Mowat-Wilson syndrome phenotype.
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| Heinritz W, Zweier C, Froster UG, Strenge S, Kujat A, Syrbe S, Rauch A, Schuster V.
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| Am J Med Genet A 140(11):1223-7. 2006
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| 35 | ZEB2, MOWS
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| Recurrence of Mowat-Wilson syndrome in siblings with the same proven mutation.
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| McGaughran J, Sinnott S, Dastot-Le Moal F, Wilson M, Mowat D, Sutton B, Goossens M.
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| Am J Med Genet A 137(3):302-4. 2005
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| 36 | ZEB2, MOWS
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| Genitourinary anomalies in Mowat-Wilson syndrome with deletion/mutation in the zinc finger homeo box 1B gene (ZFHX1B). Report of three Italian cases with hypospadias and review.
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| Garavelli L, Cerruti-Mainardi P, Virdis R, Pedori S, Pastore G, Godi M, Provera S, Rauch A, Zweier C, Zollino M, Banchini G, Longo N, Mowat D, Neri G, Bernasconi S.
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| Horm Res 63(4):187-92. Epub 2005 May 20. 2005
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| 37 | ZEB2
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| SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions.
|
| Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, Andersen H, Tulchinsky E, Van Roy F, Berx G.
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| Nucleic Acids Res 33(20):6566-78. Print 2005. 2005
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| 38 | ZEB2, MOWS
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| Clinical and molecular analysis of Mowat-Wilson syndrome associated with ZFHX1B mutations and deletions at 2q22-q24.1.
|
| Ishihara N, Yamada K, Yamada Y, Miura K, Kato J, Kuwabara N, Hara Y, Kobayashi Y, Hoshino K, Nomura Y, Mimaki M, Ohya K, Matsushima M, Nitta H, Tanaka K, Segawa M, Ohki T, Ezoe T, Kumagai T, Onuma A, Kuroda T, Yoneda M, Yamanaka T, Saeki M, Segawa M, Saji T, Nagaya M, Wakamatsu N.
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| J Med Genet 41(5):387-93. No abstract available. 2004
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| 39 | AIC, AXR2, CCA, CDG1D, DHOF, DPYD, HPE2, JBTS1, MCIA, MCOPCB2, MKS1, MRXS28, NBCCS2, NS1, OFCD, ONCR, OOD1, OPD2, RBP4, RIEG1, RSTS, TCOF1, WLKWS1, ZEB2
|
| Ocular coloboma: a reassessment in the age of molecular neuroscience.
|
| Gregory-Evans CY, Williams MJ, Halford S, Gregory-Evans K.
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| J Med Genet 41(12):881-91. 2004
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| 40 | ZEB2, MOWS
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| Mowat-Wilson syndrome and mutation in the zinc finger homeo box 1B gene: a well defined clinical entity.
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| Cerruti Mainardi P, Pastore G, Zweier C, Rauch A.
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| J Med Genet 41(2):e16. No abstract available. 2004
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| 41 | ZEB2, MOWS
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| Mowat-Wilson syndrome.
|
| Mowat DR, Wilson MJ, Goossens M.
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| J Med Genet 40(5):305-10. Review. 2003
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| 42 | ZEB2, MOWS
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| Further delineation of the phenotype associated with heterozygous mutations in ZFHX1B.
|
| Wilson M, Mowat D, Dastot-Le Moal F, Cacheux V, Kaariainen H, Cass D, Donnai D, Clayton-Smith J, Townshend S, Curry C, Gattas M, Braddock S, Kerr B, Aftimos S, Zehnwirth H, Barrey C, Goossens M.
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| Am J Med Genet 119A(3):257-65. 2003
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| 43 | ZEB2, MOWS
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| Mowat-Wilson syndrome with and without Hirschsprung disease is a distinct, recognizable multiple congenital anomalies-mental retardation syndrome caused by mutations in the zinc finger homeo box 1B gene.
|
| Zweier C, Albrecht B, Mitulla B, Behrens R, Beese M, Gillessen-Kaesbach G, Rott HD, Rauch A.
|
| Am J Med Genet 108(3):177-81. 2002
|
| 44 | KYNU, ZEB2, MOWS
|
| Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease.
|
| Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M.
|
| Nat Genet 27(4):369-70. 2001
|
| 45 | HNMT, ZEB2, MOWS
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| Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease.
|
| Cacheux V, Dastot-Le Moal F, Kaariainen H, Bondurand N, Rintala R, Boissier B, Wilson M, Mowat D, Goossens M.
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| Hum Mol Genet 10(14):1503-10. 2001
|
| 46 | ZEB2, MOWS
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| Large-scale deletions and SMADIP1 truncating mutations in syndromic Hirschsprung disease with involvement of midline structures.
|
| Amiel J, Espinosa-Parrilla Y, Steffann J, Gosset P, Pelet A, Prieur M, Boute O, Choiset A, Lacombe D, Philip N, Le Merrer M, Tanaka H, Till M, Touraine R, Toutain A, Vekemans M, Munnich A, Lyonnet S.
|
| Am J Hum Genet 69(6):1370-7. 2001
|
| 47 | ZEB2, MOWS
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| Nonsense and frameshift mutations in ZFHX1B, encoding Smad-interacting protein 1, cause a complex developmental disorder with a great variety of clinical features.
|
| Yamada K, Yamada Y, Nomura N, Miura K, Wakako R, Hayakawa C, Matsumoto A, Kumagai T, Yoshimura I, Miyazaki S, Kato K, Sonta S, Ono H, Yamanaka T, Nagaya M, Wakamatsu N.
|
| Am J Hum Genet 69(6):1178-85. 2001
|
| 48 | ZEB2
|
| The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion.
|
| Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, Mareel M, Huylebroeck D, van Roy F.
|
| Mol Cell 7(6):1267-78. 2001
|
| 49 | ZEB2, MOWS
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| Hirschsprung disease, microcephaly, mental retardation, and characteristic facial features : delineation of a new syndrome and identification of a locus at chromosome 2q22-q23.
|
| Mowat DR, et al.
|
| J Med Genet 35 : 617-623. 1998
|