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FLASH GENE
Symbol KIF5C contributors: shn/npt/pgu - updated : 08-11-2013
HGNC name kinesin family member 5C
HGNC id 6325
Corresponding disease
CDCBM2 cortical dysplasia, complex, with other brain malformations 2
Location 2q23.3      Physical location : 149.632.818 - 149.883.273
Synonym name kinesin, heavy chain, neuron specific
Synonym symbol(s) KINN, NKHC, NKHC2, NKHC-2, FLJ44735, KIAA0531, MGC111478, CDCBM2
DNA
TYPE functioning gene
STRUCTURE 242.23 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D2S2335 - D2S2184 - KIF5C - D2S2324 - D2S2277 - qter
Physical map
FLJ11753 2q22.3-q23.1 hypothetical protein FLJ11753 LOC387627 2 hypothetical gene supported by NM_014118 ZFHX1B 2q22 zinc finger homeobox 1b LOC200583 2q23.2-q23.3 similar to Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1) ACVR2 2q22.2-q23.3 activin A receptor, type II ORC4L 2q22-q23 origin recognition complex, subunit 4-like (yeast) MBD5 2q23.2 methyl-CpG binding domain protein 5 DKFZP566F2124 2q23.3 DKFZP566F2124 protein UBBP3 2q22.3 ubiquitin B pseudogene 3 LOC344172 2q23.3 similar to ubiquitin specific protease 8 LOC391451 2 similar to Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) KIF5C 2q22.3-q32 kinesin family member 5C LOC151276 2q23.3 thioredoxin 1 pseudogene 1 LOC130576 2q23.3 hypothetical protein LOC130576 MGC52057 2q23.3 hypothetical protein MGC52057 CL25022 2q23.3 hypothetical protein CL25022 FLJ32955 2q23.3 hypothetical protein FLJ32955 ARHE 2q23.3 ras homolog gene family, member E LOC339782 2q23.3 hypothetical LOC339782 LOC344332 2q23.3 similar to Fatty acid-binding protein, epidermal (E-FABP) (Psoriasis-associated fatty acid-binding protein homolog) (PA-FABP) LOC389054 2 similar to FLJ45645 protein NMI 22q13.3 N-myc (and STAT) interactor TNFAIP6 2q23.3 tumor necrosis factor, alpha-induced protein 6 DKFZP434D193 2q24.1 DKFZP434D193 protein NEB 2q21.2-q22 nebulin ARL5 2q23.3 ADP-ribosylation factor-like 5 CACNB4 2q22-q23 calcium channel, voltage-dependent, beta 4 subunit STAM2 2q24.1 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 NUDCP1 2q23-q24 nuclear distribution gene C homolog (A. nidulans) pseudogene 1 FNBP3 2q23.3 formin binding protein 3 MGC33864 2q24.1 ADP-ribosylation-like factor 6-interacting protein 6 LOC391452 2 similar to ATP synthase B chain, mitochondrial precursor LOC391453 2 similar to ribosomal protein L23a REPRIMO 2q24.1 candidate mediator of the p53-dependent G2 arrest GALNT13 2q24.1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
25 - 6927 100 957 - 1998 9628581
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 nerve    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a kinesin motor catalytic domain
  • a GRIF-1 binding domain
  • a large globular N- terminal domain responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule)
  • a central alpha-helical coiled coil domain mediating the heavy chain dimerization
  • a phosphorylation site for CSNK2A1 mapped to AA 338 located in the non-motor domain (threonine 338, within the alpha-helical coiled-coil domain which is called the neck domain is the major phosphorylation site for CSNK2A1)
  • a small globular C-terminal domain which interacts with other proteins, C-terminal EYFP-tagged KIF5C, non-motor domain
  • mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies ortholog to Kif5c, Rattus norvegicus
    ortholog to Kif5c, Mus musculus
    ortholog to KIF5C, Pan troglodytes
    ortholog to CH211-157C24.3, Danio rerio
    intraspecies paralog to KIF5A and KIF5B
    Homologene
    FAMILY
  • kinesin-like protein family
  • CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • function as adaptors in the anterograde trafficking of organelles to synapses
  • maintenance of motor neurons
  • microtubule-associated force-producing protein that may play a role in organelle transport
  • motor proteins which transport specific cargoes along the microtubules
  • complex of KIF5C, KLC1 and CRMP2 is involved in transporting tubulin heterodimers and oligomers to the tip of the growing axon
  • imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array
  • KIF5C is a new binding partner for CSNK2A2, CSNK2A1
  • kinesin motor for apical trafficking of both raft-associated sucrase isomaltase and raft-independent neurotrophin receptor
  • is involved in the passage of apical cargo molecules to a post-Golgi endosomal compartment, where further segregation into distinct vesicle populations proceeds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system , cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component oligomer composed of two heavy chains and two light chains
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • trafficking protein kinesin binding TRAK1, trafficking protein kinesin binding 2 (TRAK2) and kinesin light chain 3 (KLC3)
  • substrate for CSNK2A1 (phosphorylated by CSNK2A1, phosphorylation that will influence the dimerization of KIF5C)
  • kinesin light chain 1 (KlC1) and collapsin response mediator protein 2 (CRMP2)
  • interacts with adjacent microtubules in the mitotic spindle
  • endogenously bind the full-length variant of VHL (pVHL30) in primary kidney cells, and mediate its association to microtubules
  • ZFYVE27 interact with other hereditary spastic paraplegia-related proteins including myelin proteolipid protein 1 (PLP1), atlastin-1 (ATL1), REEP1, REEP5 (similar to REEP1), KIF5A, KIF5B, KIF5C
  • cell & other
  • associated with microtubules
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDCBM2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS