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FLASH GENE

Symbol

KYNU

contributors: - updated : 17-10-2006

HGNC name	kynureninase (L-kynurenine hydrolase)
HGNC id	6469

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	KYNU hydroxykynureninuria / kynureninase deficiency
Location	2q22.2      Physical location : 143.635.194 - 143.799.884
EC.number	3.7.1.33

DNA

TYPE	functioning gene
STRUCTURE	164.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 1688 - 465 - Toma V2 - - 1315 - 307 - Toma

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver       highly   liver       highly Nervous brain         Reproductive female system uterus cervix   highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies

homolog to rattus Kynu

Homologene

FAMILY

kynureninase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

kynurenine pathway

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	pyridoxal phosphate

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

KYNU

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS