| Symbol
| YWHAE
| contributors: mct/ - updated : 19-09-2019
|
| HGNC name
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
|
| HGNC id
| 12851
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
| |
in gastric cancer | | tumoral
|
| deletion
|
|
| |
in small cell lung cancer | | constitutional
|
|
| --low
|
|
synaptic reduction of DISC1 and YWHAE is developmentally correlated with the age-dependent decrease in striatal spine density  | |
| Susceptibility
|
to schizophrenia |
| Variant & Polymorphism
SNP
| SNP which influence the expression of 14-3-3 epsilon RNA and protein, is associated with schizophrenia and seems to work protectively |
| 
|
Candidate gene
| Marker
| may serve as a novel prognostic biomarker for hepatocellular carcinoma (HCC) | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| immunology | inflammatory | | |
| YWHAE/ANPEP interaction could be a new therapeutic target in osteoarthritis | | cancer | digestive | stomach | |
| may serve as a therapeutic target for hepatocellular carcinoma (HCC) |
| | |
|
| Ywhae knockout mouse is useful for pathophysiological analyses of neuropsychiatric disorders caused by defects during neurodevelopment 7) |