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FLASH GENE
Symbol YWHAE contributors: mct/ - updated : 19-09-2019
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
HGNC id 12851
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   predominantly
Digestiveesophagus   highly
 intestinesmall intestine  moderately
 liver   moderately
 mouthtongue  moderately
Endocrineparathyroid   moderately
Nervousbrain   moderately
 nerve   moderately
Reproductivefemale systemuteruscervix moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Ywhae (98.8pc)
ortholog to murine Ywhae (99.6pc)
Homologene
FAMILY
  • 14-3-3 family
  • CATEGORY adaptor , regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator required for cytoplasmic dynein function, neuronal migration and brain development
  • implicated in the regulation of a large spectrum of both general and specialized signaling pathway
  • playing a crucial role in neronal development by sustaining the effects of CDK5 phosphorylation
  • involved in the proper localization of NDEL1 and PAFAH1B1 in axons
  • YWHAE and DISC1, two schizophrenia susceptibility factors have been implicated in the regulation of spine density
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complex LIS1/CDK5/NDEL1/YWHAE, pathway in neuronal migration and development
  • HDAC7 directly binds to beta-catenin and forms a complex with YWHAE, YWHAZ, and YWHAH proteins
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • p38 MAP kinase
  • LIS1 and NDEL1 (maintaining phosphorylation of NDEL1)
  • KCNH2 (to control the membrane excitability and cardiac rhythm)
  • HCV core protein
  • forms a complex with DISC1 (both DISC1 and YWHAE are required for neuronal development via transport of the NUDEL/LIS1 complex
  • interaction with YWHAB, ATXN1, YWHAH, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • YWHAE interacts with the kinase domain of MAP3K5 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation
  • cell & other
    REGULATION
    activated by Cl-channel with CLCA1
    ASSOCIATED DISORDERS
    corresponding disease(s) MDS , DEL17P13D , DUP17P13
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral   deletion    
    in small cell lung cancer
    constitutional     --low  
    synaptic reduction of DISC1 and YWHAE is developmentally correlated with the age-dependent decrease in striatal spine density
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP SNP which influence the expression of 14-3-3 epsilon RNA and protein, is associated with schizophrenia and seems to work protectively
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS