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FLASH GENE
Symbol YWHAE contributors: mct/ - updated : 19-09-2019
HGNC name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
HGNC id 12851
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Mus musculusFetal
 vessel   predominantly
Digestiveesophagus   highly
 intestinesmall intestine  moderately
 liver   moderately
 mouthtongue  moderately
Endocrineparathyroid   moderately
Nervousbrain   moderately
Reproductivefemale systemuteruscervix moderately
Visualeyeretina  predominantly Mus musculus
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac   Mus musculusFetal
cells
SystemCellPubmedSpeciesStageRna symbol
Muscularmyocyte Mus musculusFetal
Visualrod photoreceptor Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to rattus Ywhae (98.8pc)
ortholog to murine Ywhae (99.6pc)
Homologene
FAMILY
  • 14-3-3 family
  • CATEGORY adaptor , regulatory , signaling neurotransmitter
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • inhibitor of apoptosis through inhibiting the activation of p38 MAP kinase
  • multifunctional regulator required for cytoplasmic dynein function, neuronal migration and brain development
  • implicated in the regulation of a large spectrum of both general and specialized signaling pathway
  • playing a crucial role in neronal development by sustaining the effects of CDK5 phosphorylation
  • involved in the proper localization of NDEL1 and PAFAH1B1 in axons
  • YWHAE and DISC1, two schizophrenia susceptibility factors have been implicated in the regulation of spine density
  • is a key component of a DDX58 translocon required for innate antiviral immunity
  • may act as an important regulator in modulating tumor metastasis by promoting EMT as well as cell migration
  • subchondral bone soluble mediator altering cartilage homeostasis
  • CDK5, YWHAE, and CDK5 cofactor C2CD5 together promote NDEL1 phosphorylation and are essential for force adaptation
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complex LIS1/CDK5/NDEL1/YWHAE, pathway in neuronal migration and development
  • HDAC7 directly binds to beta-catenin and forms a complex with YWHAE, YWHAZ, and YWHAH proteins
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • p38 MAP kinase
  • LIS1 and NDEL1 (maintaining phosphorylation of NDEL1)
  • KCNH2 (to control the membrane excitability and cardiac rhythm)
  • HCV core protein
  • forms a complex with DISC1 (both DISC1 and YWHAE are required for neuronal development via transport of the NUDEL/LIS1 complex
  • interaction with YWHAB, ATXN1, YWHAH, YWHAZ mediated by AKT1 to modulate the neurotoxicity of SCA1
  • regulates cardiogenesis and growth of the compact ventricular myocardium by modulating the cardiomyocyte cell cycle via both CCNE1 and CDKN1B
  • interaction between NAV2 and YWHAE could provide insight into the mechanism by which NAV2 participates in promoting cell migration and neuronal elongation
  • YWHAE interacts with the kinase domain of MAP3K5 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation
  • cell & other
    REGULATION
    activated by Cl-channel with CLCA1
    ASSOCIATED DISORDERS
    corresponding disease(s) MDS , DEL17P13D , DUP17P13
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer
    tumoral   deletion    
    in small cell lung cancer
    constitutional     --low  
    synaptic reduction of DISC1 and YWHAE is developmentally correlated with the age-dependent decrease in striatal spine density
    Susceptibility to schizophrenia
    Variant & Polymorphism SNP SNP which influence the expression of 14-3-3 epsilon RNA and protein, is associated with schizophrenia and seems to work protectively
    Candidate gene
    Marker may serve as a novel prognostic biomarker for hepatocellular carcinoma (HCC)
    Therapy target
    SystemTypeDisorderPubmed
    immunologyinflammatory 
    YWHAE/ANPEP interaction could be a new therapeutic target in osteoarthritis
    cancerdigestivestomach
    may serve as a therapeutic target for hepatocellular carcinoma (HCC)
    ANIMAL & CELL MODELS
  • Ywhae knockout mouse is useful for pathophysiological analyses of neuropsychiatric disorders caused by defects during neurodevelopment 7)