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FLASH GENE
Symbol TPH1 contributors: mct/npt - updated : 10-02-2009
HGNC name tryptophan hydroxylase 1
HGNC id 12008
Location 11p15.1      Physical location : 18.042.083 - 18.062.335
Synonym name
  • tryptophan hydroxylase 1 (tryptophan 5-monooxygenase)
  • tryptophan 5-monooxygenase
  • indoleacetic acid-5-hydroxylase
    • Synonym symbol(s) TRPH , TPH, DELGEF, MGC119994, TPRH
    EC.number 1.14.16.4
    DNA
    TYPE like-sequence
    STRUCTURE 19.77 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure pter in binding site
    MAPPING cloned Y linked Y status confirmed
    Map pter - TH - D11S1 - D11S12 - HBB ,D11S30 - D11S20 - CALCA ,TPH1 - LDHA ,SAA2 ,D11S18 ,D11S21 ,D11S31 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1335 51 444 - Nielsen (1992)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Reproductivefemale systemuterus   
    Respiratorylung    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ACT domain
    • mono polymer heptamer
    HOMOLOGY
    Homologene
    FAMILY
  • biopterin-dependent aromatic amino acid hydroxylase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • catalyses the rate-limiting step in the biosynthesis of serotonin (Winge 2007)
  • catalyzing the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • ferrous ion
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to shizophrenia (rs1800532)
  • to heroin addiction
    • Variant & Polymorphism other association of a specific TPH1 haplotype with heroin addiction (Nielsen 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS