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FLASH GENE

Symbol

WFDC2

contributors: mct - updated : 20-06-2011

HGNC name	WAP four-disulfide core domain 2
HGNC id	15939

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	11.78 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006103 4 - 570 - 124 - 1998 9685187

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol   epididymis         Homo sapiens Digestive mouth tongue     highly Homo sapiens   salivary gland       highly Homo sapiens Respiratory lung         Homo sapiens   respiratory tract trachea     highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide followed by an acidic and cysteine rich polypeptide
	two WAP domains, WAP domains playing pivotal roles in the antimicrobial and/or antiprotease activities and their application in therapeutics are expected to have practical value
	a conserved motif, containing eight cysteines

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to proteinase inhibitous,four disulfide core proteins

Homologene

FAMILY

CATEGORY

regulatory , secretory

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	potentially involved in sperm maturation
	a putative serum tumour marker for ovarian cancer
	may be a component of the innate immune defences of the lung, nasal and oral cavities
	functions in concert with related WAP domain containing proteins in epithelial host defence
	its expression is associated with cancer cell adhesion, migration and tumor growth, which can be related to its effects on the EGFR-MAPK signaling pathway
	participates in the process of ovarian cancer cell maturation and is responsible for engaging the progression of the ovarian cancer

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

plays an important role in ovarian cancer cell migration and spreading

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian carcinomas tumoral     --over   significantly increased in patients with transitional cell carcinoma (TCC)in the urinary system compared to patients with benign urinary diseases patients constitutional     --over   Significant increases in expression and localisation of WFDC2 are seen in patients with Cystic Fibrosis (

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	its expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence
	measuring WFDC2 in urine may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma
	may be a screening tool for early diagnosis of TCC in the urinary system, and may become a prognostic marker for TCC in the urinary system
	novel and specific biomarker for epithelial ovarian cancer (EOC)
Therapy target
	System Type Disorder Pubmed cancer reproductive ovary may aid diagnosis and the monitoring of response to therapy, in ovarian carcinoma

ANIMAL & CELL MODELS