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FLASH GENE
Symbol YARS2 contributors: mct - updated : 22-09-2015
HGNC name tyrosyl-tRNA synthetase 2, mitochondrial
HGNC id 24249
Corresponding disease
MLASA2 myopathy, lactic acidosis, and sideroblastic anemia 2
Location 12p11.21      Physical location : 32.899.478 - 32.908.874
Synonym name
  • CGI-04 protein
  • tyrosine--tRNA ligase
    • Synonym symbol(s) CGI-04, FLJ13995, mt-TyrRS, TYRRS
    EC.number 6.1.1.1
    DNA
    TYPE functioning gene
    STRUCTURE 9.40 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2179 - 477 - 2005 15840810
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus norvegicus RGD31696
    Homologene
    FAMILY
  • class-I aminoacyl-tRNA synthetase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • tyrosine-tRNA ligase activity
  • catalyzes covalent binding of tyrosine to its cognate tRNA (Riley (2010)
  • likely increased requirement for YARS2 as muscle cells differentiate
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text protein biosynthesis ; tyrosyl-tRNA aminoacylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding tRNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLASA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS