Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol YARS2 contributors: mct - updated : 22-09-2015
HGNC name tyrosyl-tRNA synthetase 2, mitochondrial
HGNC id 24249
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus norvegicus RGD31696
Homologene
FAMILY
  • class-I aminoacyl-tRNA synthetase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • tyrosine-tRNA ligase activity
  • catalyzes covalent binding of tyrosine to its cognate tRNA (Riley (2010)
  • likely increased requirement for YARS2 as muscle cells differentiate
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text protein biosynthesis ; tyrosyl-tRNA aminoacylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding tRNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLASA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS