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FLASH GENE
Symbol YARS2 contributors: mct - updated : 22-09-2015
HGNC name tyrosyl-tRNA synthetase 2, mitochondrial
HGNC id 24249
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus norvegicus RGD31696
Homologene
FAMILY
  • class-I aminoacyl-tRNA synthetase family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • tyrosine-tRNA ligase activity
  • catalyzes covalent binding of tyrosine to its cognate tRNA (Riley (2010)
  • likely increased requirement for YARS2 as muscle cells differentiate
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    text protein biosynthesis ; tyrosyl-tRNA aminoacylation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding tRNA
    small molecule nucleotide,
  • ATP
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MLASA2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS