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Symbol WNT7A contributors: shn/npt/pgu - updated : 14-12-2018
HGNC name wingless-type MMTV integration site family, member 7A
HGNC id 12786
Corresponding disease
FACFB fibular agenesis/ hypoplasia, clubfeet, brachydactyly
LPHAS limb/pelvis-hypoplasia/aplasia syndrome
Location 3p25.1      Physical location : 13.860.081 - 13.921.618
Synonym name
  • proto-oncogene Wnt7a protein
  • protein Wnt-7a
  • DNA
    TYPE functioning gene
    STRUCTURE 61.54 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D3S2403 - D3S3608 - WNT7A - D3S1585 - D3S1554 - qter
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1732 - 349 central nervous system 2003 12857724
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain     Homo sapiens
    Reproductivefemale systemuterus   
     female systemplacenta   
     male systemtestis   
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia Homo sapiens
    cell lineage
    cell lines
    at STAGE
    physiological period fetal
    Text lung and brain
  • cysteine rich domains
  • conjugated GlycoP
    interspecies ortholog to Wnt7a, Mus musculus
    ortholog to Wnt7a, Rattus norvegicus
    homolog to LOC749914, Pan troglodytes
    ortholog to wnt7a, Danio rerio
  • wingless-type MMTV integration site family
  • CATEGORY secretory , protooncogene , signaling
        plasma membrane
    basic FUNCTION
  • role in limb development and cell transformation
  • plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function
  • implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis
  • controlling limb development at the dorsoventral axis
  • modulating cell fate and cell behavior during vertebrate development
  • upregulating LMX1A expression in limbs mesenchyme and dorsal differentiation
  • associated with cartilage destruction by regulating the maintenance of differentiation status and the apoptosis of articular chondrocytes via different mechanisms
  • playing a critical role in uterine smooth muscle pattering and maintenance of adult uterine function
  • involved in the development of the anterior-posterior axis in the female reproductive tract and in uterine smooth muscle pattering and maintenance of adult uterine function
  • capable of modulating aspects of neuronal plasticity
  • promoted the maturation of neural precursor cells into neurons
  • plays a role in cerebellar maturation
  • modulate the synaptic vesicle cycle and synaptic neurotransmission in mature hippocampal neurons
  • increases the clustering of synapsin 1 in granule cells
  • role in the regulation of organ-specific assembly and in the differentiation of the central nervous system vasculature
  • preferentially stimulates excitatory synapse formation and function
  • WNT7A signaling is critical to regulate spine growth and synaptic strength through the local activation of CAMK2 at dendritic spines
  • unique role in specifically promoting the formation and function of excitatory synapses in the hippocampus through the regulation of spine morphogenesis and synaptic strength
  • FN1 and WNT7A together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis
  • WNT7A exercised critical control over multiple steps of neurogenesis by regulating genes involved in both cell cycle control and neuronal differentiation
  • WNT7A is a new regulator of ventral midbrain (VM) neurogenesis and dopaminergic (DA) axon growth and guidance
  • central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination
  • WNT7A induced cellular senescence via inactivation of S-phase kinase-associated protein 2, an important alternate regulator of cellular senescence
  • secreted glycoprotein that plays a critical role in tumorigenesis and development by controlling cell proliferation and differentiation
  • induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines
  • has likely important role in tooth development and its mutation may lead to tooth agenesis, microdontia, and taurodontism
  • WNT7A and SFRP1 play likely opposite roles to ensure proper neural progenitors (NP) progeny in the developing cortex
  • hypoxia induced high expression of WNT7A might promote the cell migration via enhancing the epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma
  • WNT7A promotes the migration capacity of cancer cell
  • CELLULAR PROCESS cell communication
    signaling signal transduction
  • WNT7A-DVL1 signaling is required for spine morphogenesis and glutamatergic transmission in the hippocampus
  • ITGB1-WNT7A-DCN pathway promotes proliferation and differentiation of neuroepithelial cells, and identify DCN as a novel neurogenic factor in the central nervous system
  • a component
    small molecule
  • interacting with PORCN
  • frizzled homolog 5, FZD5 and low density lipoprotein receptor-related protein 6, LRP6
  • frizzled homolog 9 (Drosophila), FZD9
  • FZD5 is a receptor for the synaptic organizer WNT7A, regulating activity-mediated synaptogenesis
  • DVL1 is required for WNT7A function
  • central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination
  • RECK and GPR124 are part of the cell surface protein complex that transduces WNT7A- and WNT7B-specific signals in mammalian CNS endothelial cells (ECs) to promote angiogenesis and regulate the Blood-Brain Barrier
  • interplay of NDP and WNT7A/WNT7B signaling systems in blood-brain barrier and blood-retina barrier development and maintenance
  • cell & other
    corresponding disease(s) LPHAS , FACFB
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in lung cancer in development or in progression (by its effect on E-cadherin)
    tumoral     --over  
    in pancreatic and gastric cancer
    tumoral     --low  
    in uterine leiomyoma inversely associated with the expression of estrogen receptor-alpha
    tumoral     --over  
    in pancreatic cancer tissue compared with the adjacent non-tumor tissue and the expression of WNT7A positively correlates with poor prognosis and lymph node metastasis
    tumoral     --over  
    in most colorectal cancer tissues but weakly expressed in adjacent normal mucosa, colorectal adenomas, and colonic polyps
    constitutional       loss of function
    induces limbal stem or progenitor cells (LSCs) into skin-like epithelium, a critical defect tightly linked to common human corneal diseases
    Variant & Polymorphism
    Candidate gene
  • positive WNT7A, in addition to TNM stage, may be an independent prognosis factor influencingoverall survival (OS) and disease-free survival (DFS) prediction in Colorectal cancer patients
  • Therapy target
    WNT7A is a potential treatment for muscle-wasting diseases
  • male mice lacking Wnt-7a fail to undergo regression of the Müllerian duct resulting of the absence of the receptor for Müllerian-inhibiting substance and Wnt7a-deficient females mice are infertile due to abnormal oviduct and uterus development
  • double-mutant mouse lacking both WNT7A and the downstream scaffold protein Dishevelled display defect in the release of neurotransmitter and localization of synaptic proteins is affected
  • Wnt7a-Dvl1–deficient mice exhibit defects in spine morphogenesis and mossy fiber-CA3 synaptic transmission in the hippocampus