SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,cytoplasm,cytoskeleton,intermed filament
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text
| localize to the cilium |
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WDR35 is present in the endoplasmic reticulum, but usually not in lysosomes |
basic FUNCTION
| involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation |
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having a ciliary function |
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may function as a novel modulator activating caspase-3, and promoting TNF-alpha-stimulated apoptosis |
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required for mammalian ciliogenesis |
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WDR35 regulates cilium assembly by selectively regulating transport of distinct cargoes |
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WDR35 is essential for entry of many membrane proteins into the cilium through robust interactions with cargoes and other IFT-A subunits, but the actin network functions to dampen this transport |