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FLASH GENE
Symbol WDR35 contributors: mct - updated : 22-12-2020
HGNC name WD repeat domain 35
HGNC id 29250
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal WD40 four repeats
  • C-terminal tetratricopeptide repeat (TPR)-like motifs
  • HOMOLOGY
    interspecies ortholog to C. elegans protein IFTA-1
    intraspecies homolog to TULP4
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localize to the cilium
  • WDR35 is present in the endoplasmic reticulum, but usually not in lysosomes
  • basic FUNCTION
  • involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation
  • having a ciliary function
  • may function as a novel modulator activating caspase-3, and promoting TNF-alpha-stimulated apoptosis
  • required for mammalian ciliogenesis
  • WDR35 regulates cilium assembly by selectively regulating transport of distinct cargoes
  • WDR35 is essential for entry of many membrane proteins into the cilium through robust interactions with cargoes and other IFT-A subunits, but the actin network functions to dampen this transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • intraflagellar transport component
  • IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT43 directly interacts with WDR35 and loss of IFT43 results in instability of IFT-A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETD2 , SRPS5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulated WDR35 may damage the cilia formation and sequentially indirectly regulate GLI signal, which would eventually result in negative regulation of osteogenic differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS