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FLASH GENE
Symbol WDR35 contributors: mct - updated : 22-12-2020
HGNC name WD repeat domain 35
HGNC id 29250
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 6924 132.3 1170 - 2010 20193664
28 - 6957 - 1181 - 2010 20193664
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Gustatory (taste)tongue    
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal WD40 four repeats
  • C-terminal tetratricopeptide repeat (TPR)-like motifs
  • HOMOLOGY
    interspecies ortholog to C. elegans protein IFTA-1
    intraspecies homolog to TULP4
    Homologene
    FAMILY
  • WD repeat gene family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text
  • localize to the cilium
  • WDR35 is present in the endoplasmic reticulum, but usually not in lysosomes
  • basic FUNCTION
  • involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation
  • having a ciliary function
  • may function as a novel modulator activating caspase-3, and promoting TNF-alpha-stimulated apoptosis
  • required for mammalian ciliogenesis
  • WDR35 regulates cilium assembly by selectively regulating transport of distinct cargoes
  • WDR35 is essential for entry of many membrane proteins into the cilium through robust interactions with cargoes and other IFT-A subunits, but the actin network functions to dampen this transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • intraflagellar transport component
  • IFT-A protein complex consists of IFT43, WDR35, IFT122, TTC21B, IFT140 and WDR19 and is associated with THM1 and TULP3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IFT43 directly interacts with WDR35 and loss of IFT43 results in instability of IFT-A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CETD2 , SRPS5
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    down-regulated WDR35 may damage the cilia formation and sequentially indirectly regulate GLI signal, which would eventually result in negative regulation of osteogenic differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS