| protein
| bound with high affinity to clathrin |
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with complex DER1/ VIMP that serves as a receptor for VCP |
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binding to ATXN3 |
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binding partner of FAF1 |
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HIF1A is the first endogenous substrate of VCP that is not associated with the ER |
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interacting with TARDBP (VCP gene mutations lead to a dominant negative loss or alteration of VCP function culminating in impaired degradation of TARDBP)  |
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ER lumenal domain of MKS3 interacted with a complex that included mutant SFTPC and associated chaperones, whereas the region predicted to encode the transmembrane domains of MKS3 interacted with cytosolic VCP |
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NSFL1C is a VCP-binding protein, that functions in Golgi membrane fusion together with VCP and VCPIP1, another VCP-binding protein |
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potential synergistic cooperation between VCP and ATXN3 in ubiquitin-mediated proteolysis and ageing regulation |
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ASPSCR1 controls VCP oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types |
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is an activator specifically of wild-type ATXN3, exhibiting no effect on expanded ATXN3 |
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VCP regulation by PTPN13 might be important for tumorigenesis |
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SPRTN recruits VCP to sites of DNA damage |
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VCP, an enzyme with segregase and unfoldase activity, is a key player in TRIM21-mediated virus neutralization |
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function directly with 20S peptidase to maintain intracellular protein quality control |
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directly binds to multiple polyglutamine disease proteins (huntingtin, ataxin-1, ataxin-7 and androgen receptor) via polyglutamine sequence |
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UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA |
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NUB1L directly interacted with NEDD8, but not with ubiquitin, on the key residue Asn-51 of NEDD8 and with VCP on its positively charged VCP binding motif |
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SIK2 co-localizes with VCP in the ER membrane and stimulates its ATPase activity through direct phosphorylation |
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proteasome-mediated processing of NFE2L1 is essential for coordinate induction of all proteasome subunits and VCP |
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interactions between FUS and proteins involved in neurodegenerative diseases and/or ubiquitin proteasome pathway, such as VCP, SFPQ, UBA1, and 26S proteosome non-ATPase regulatory subunit 12 (PSMD12) |
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VCP/p97 cooperates with YOD1, UBXN6 and PLAA to drive clearance of ruptured lysosomes by autophagy |
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UBXN7, adaptor of VCP ATPase, can participate in the degradation of misfolded or damaged proteins in the VCP-mediated ubiquitin proteasome system (UPS) |
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may have a cooperative effect on VCP interaction with UFD1L |
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METTL21C trimethylates VCP on the Lys315 residue and loss of this modification reduced VCP hexamer formation and ATPase activity |
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VCP-ATXN3 complex is the essential machinery for regulation of RNF8 homeostasis under both physiological and genotoxic conditions |
