| 1 | DDHDM, VCP
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| An autosomal-dominant childhood-onset disorder associated with pathogenic variants in VCP
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| Mah-Som AY, Daw J, Huynh D, Wu M, Creekmore BC, Burns W, Skinner SA, Holla ØL, Smeland MF, Planes M, Uguen K, Redon S, Bierhals T, Scholz T, Denecke J, Mensah MA, Sczakiel HL, Tichy H, Verheyen S, Blatterer J, Schreiner E, Thies J, Lam C, Spaeth CG, Pena L, Ramsey K, Narayanan V, Seaver LH, Rodriguez D, Afenjar A, Burglen L, Lee EB, Chou TF, Weihl CC, Shinawi MS.
|
| Am J Hum Genet. Nov 2;110(11):1959-1975. doi: 10.1016/j.ajhg.2023.10.007. Epub 2023 Oct 25 2023
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| 2 | VCP
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| p97/VCP Promotes the Recycling of Endocytic Cargo.
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| Kawan M, Körner M, Schlosser A, Buchberger A.
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| Mol Biol Cell. Dec 1;34(13):ar126. doi: 10.1091/mbc.E23-06-0237. Epub 2023 Sep 27. 2023
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| 3 | IBMPFD, VCP
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| P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration.
|
| Wang F, Li S, Wang TY, Lopez GA, Antoshechkin I, Chou TF.
|
| Brain Commun. Jul 6;4(4):fcac176. doi: 10.1093/braincomms/fcac176. eCollection 2022. 2022
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| 4 | VCP, WIPI2
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| WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP.
|
| Lu G, Tan HWS, Schmauck-Medina T, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM.
|
| Autophagy. Dec;18(12):2865-2879. doi: 10.1080/15548627.2022.2052461. Epub 2022 Apr 7. 2022
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| 5 | NSF, VCP
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| The AAA+ superfamily: a review of the structural and mechanistic principles of these molecular machines
|
| Khan YA, White KI, Brunger AT.
|
| Crit Rev Biochem Mol Biol Apr;57(2):156-187. doi: 10.1080/10409238.2021.1979460. Epub 2021 Oct 11. 2022
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| 6 | ATXN3, BECN1, VCP
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| VCP/p97 regulates Beclin-1-dependent autophagy initiation.
|
| Hill SM, Wrobel L, Ashkenazi A, Fernandez-Estevez M, Tan K, Bürli RW, Rubinsztein DC.
|
| Nat Chem Biol. Apr;17(4):448-455. doi: 10.1038/s41589-020-00726-x. Epub 2021 Jan 28. 2021
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| 7 | ATXN3, RNF8, VCP
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| The p97-Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8.
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| Singh AN, Oehler J, Torrecilla I, Kilgas S, Li S, Vaz B, Guérillon C, Fielden J, Hernandez-Carralero E, Cabrera E, Tullis ID, Meerang M, Barber PR, Freire R, Parsons J, Vojnovic B, Kiltie AE, Mailand N, Ramadan K.
|
| EMBO J 38(21):e102361. doi: 10.15252/embj.2019102361. Epub 2019 Oct 15.
2019
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| 8 | METTL21C, VCP
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| Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. 2018 PMID:
|
| Wiederstein JL, Nolte H, Günther S, Piller T, Baraldo M, Kostin S, Bloch W, Schindler N, Sandri M, Blaauw B, Braun T, Hölper S, Krüger M
|
| Cell Rep. May 1;23(5):1342-1356. doi: 10.1016/j.celrep.2018.03.136. 2018
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| 9 | PLAA, UBXN6, VCP, YOD1
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| VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.
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| Papadopoulos C, Kirchner P, Bug M, Grum D, Koerver L, Schulze N, Poehler R, Dressler A, Fengler S, Arhzaouy K, Lux V, Ehrmann M, Weihl CC, Meyer H.
|
| EMBO J 36(2):135-150. doi: 10.15252/embj.201695148. Epub 2016 Oct 17.
2017
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| 10 | UBXN7, UFD1, VCP
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| Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase.
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| Li ZH, Wang Y, Xu M, Jiang T.
|
| Biochem Biophys Res Commun. Apr 22;486(1):94-100. doi: 10.1016/j.bbrc.2017.03.005. Epub 2017 Mar 6. 2017
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| 11 | FUS, PSMD12, SFPQ, UBA1, VCP
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| Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
|
| Wang T, Jiang X, Chen G, Xu J.
|
| Neurobiol Aging 36(1):527-35. doi: 10.1016/j.neurobiolaging.2014.07.044.
2015
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| 12 | VCP, YOD1
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| The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD).
|
| Sasset L, Petris G, Cesaratto F, Burrone OR.
|
| J Biol Chem 290(47):28175-88. doi: 10.1074/jbc.M115.656660. Epub 2015 Oct 13.
2015
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| 13 | CMT2Y, VCP
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| Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation.
|
| Jerath NU, Crockett CD, Moore SA, Shy ME, Weihl CC, Chou TF, Grider T, Gonzalez MA, Zuchner S, Swenson A.
|
| Case Rep Genet 2015:239167. doi: 10.1155/2015/239167. Epub 2015 Mar 23.
2015
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| 14 | NFE2L1, VCP
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| Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.
|
| Sha Z, Goldberg AL.
|
| Curr Biol 24(14):1573-83. doi: 10.1016/j.cub.2014.06.004. Epub 2014 Jul 3.
2014
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| 15 | CMT2Y, VCP
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| A novel mutation in VCP causes Charcot-Marie-Tooth Type 2 disease.
|
| Gonzalez MA, Feely SM, Speziani F, Strickland AV, Danzi M, Bacon C, Lee Y, Chou TF, Blanton SH, Weihl CC, Zuchner S, Shy ME.
|
| Brain 137(Pt 11):2897-902. doi: 10.1093/brain/awu224. Epub 2014 Aug 14.
2014
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| 16 | VCP
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| A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.
|
| Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.
|
| Nat Commun 4:1816. doi: 10.1038/ncomms2828.
2013
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| 17 | VCP
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| Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function.
|
| Buchan JR, Kolaitis RM, Taylor JP, Parker R.
|
| Cell 153(7):1461-74. doi: 10.1016/j.cell.2013.05.037.
2013
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| 18 | VCP
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| Role of p97/VCP (Cdc48) in genome stability.
|
| Vaz B, Halder S, Ramadan K.
|
| Front Genet 4:60. doi: 10.3389/fgene.2013.00060. Print 2013.
2013
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| 19 | VCP
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| Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction.
|
| Bergink S, Ammon T, Kern M, Schermelleh L, Leonhardt H, Jentsch S.
|
| Nat Cell Biol 15(5):526-32. doi: 10.1038/ncb2729. Epub 2013 Apr 28.
2013
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| 20 | VCP
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| Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels.
|
| Bartolome F, Wu HC, Burchell VS, Preza E, Wray S, Mahoney CJ, Fox NC, Calvo A, Canosa A, Moglia C, Mandrioli J, Chiò A, Orrell RW, Houlden H, Hardy J, Abramov AY, Plun-Favreau H.
|
| Neuron 78(1):57-64. doi: 10.1016/j.neuron.2013.02.028. Epub 2013 Mar 14.
2013
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| 21 | VCP
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| Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase.
|
| Barthelme D, Sauer RT.
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| Proc Natl Acad Sci U S A 110(9):3327-32. doi: 10.1073/pnas.1300408110. Epub 2013 Feb 11.
2013
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| 22 | CAV1, VCP
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| Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase.
|
| Kirchner P, Bug M, Meyer H.
|
| J Biol Chem 288(10):7363-72. doi: 10.1074/jbc.M112.429076. Epub 2013 Jan 19.
2013
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| 23 | PTPN13, VCP
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| Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1
|
| Abaan OD, Hendriks W, Uren A, Toretsky JA, Erkizan HV
|
| Exp Cell Res. Jan 1;319(1):1-11. doi: 10.1016/j.yexcr.2012.09.003. Epub 2012 Sep 24. 2013
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| 24 | IBMPFD, VCP
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| A novel VCP mutation as the cause of atypical IBMPFD in a Chinese family.
|
| Gu JM, Ke YH, Yue H, Liu YJ, Zhang Z, Zhang H, Hu WW, Wang C, He JW, Hu YQ, Li M, Fu WZ, Zhang ZL.
|
| Bone 52(1):9-16. doi: 10.1016/j.bone.2012.09.012. Epub 2012 Sep 19.
2013
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| 25 | FAF2, VCP
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| Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.
|
| Olzmann JA, Richter CM, Kopito RR.
|
| Proc Natl Acad Sci U S A 110(4):1345-50. doi: 10.1073/pnas.1213738110. Epub 2013 Jan 7.
2013
|
| 26 | IBMPFD, VCP
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| Genotype-phenotype studies of VCP-associated inclusion body myopathy with Paget disease of bone and/or frontotemporal dementia.
|
| Mehta SG, Khare M, Ramani R, Watts GD, Simon M, Osann KE, Donkervoort S, Dec E, Nalbandian A, Platt J, Pasquali M, Wang A, Mozaffar T, Smith CD, Kimonis VE.
|
| Clin Genet 83(5):422-31. doi: 10.1111/cge.12000. Epub 2012 Oct 4.
2013
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| 27 | NEDD8, NUB1, VCP
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| NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex.
|
| Liu S, Yang H, Zhao J, Zhang YH, Song AX, Hu HY.
|
| J Biol Chem 288(43):31339-49. doi: 10.1074/jbc.M113.484816. Epub 2013 Sep 9.
2013
|
| 28 | AURKA, NSFL1C, UBXN2B, VCP
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| The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
|
| Kress E, Schwager F, Holtackers R, Seiler J, Prodon F, Zanin E, Eiteneuer A, Toya M, Sugimoto A, Meyer H, Meraldi P, Gotta M.
|
| J Cell Biol 201(4):559-75. doi: 10.1083/jcb.201209107. Epub 2013 May 6.
2013
|
| 29 | SIK2, VCP
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| Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.
|
| Yang FC, Lin YH, Chen WH, Huang JY, Chang HY, Su SH, Wang HT, Chiang CY, Hsu PH, Tsai MD, Tan BC, Lee SC.
|
| J Biol Chem 288(47):33861-72. doi: 10.1074/jbc.M113.492199. Epub 2013 Oct 15.
2013
|
| 30 | ATXN3, VCP
|
| Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.
|
| Laço MN, Cortes L, Travis SM, Paulson HL, Rego AC.
|
| PLoS One 7(9):e43563. doi: 10.1371/journal.pone.0043563. Epub 2012 Sep 6.
2012
|
| 31 | ALS14, VCP
|
| Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.
|
| González-Pérez P, Cirulli ET, Drory VE, Dabby R, Nisipeanu P, Carasso RL, Sadeh M, Fox A, Festoff BW, Sapp PC, McKenna-Yasek D, Goldstein DB, Brown RH Jr, Blumen SC.
|
| Neurology 79(22):2201-8. doi: 10.1212/WNL.0b013e318275963b. Epub 2012 Nov 14.
2012
|
| 32 | SPRTN, VCP
|
| DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage.
|
| Davis EJ, Lachaud C, Appleton P, Macartney TJ, Näthke I, Rouse J.
|
| Nat Struct Mol Biol 19(11):1093-100. doi: 10.1038/nsmb.2394. Epub 2012 Oct 7.
2012
|
| 33 | SPRTN, VCP
|
| DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks.
|
| Mosbech A, Gibbs-Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, Nielsen SV, Smedegaard S, Sedgwick G, Lukas C, Hartmann-Petersen R, Lukas J, Choudhary C, Pocock R, Bekker-Jensen S, Mailand N.
|
| Nat Struct Mol Biol 19(11):1084-92. doi: 10.1038/nsmb.2395. Epub 2012 Oct 7.
2012
|
| 34 | VCP
|
| Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine.
|
| Barthelme D, Sauer RT.
|
| Science 337(6096):843-6. doi: 10.1126/science.1224352. Epub 2012 Jul 26.
2012
|
| 35 | VCP
|
| Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent.
|
| Esaki M, Ogura T.
|
| J Struct Biol 179(2):112-20. doi: 10.1016/j.jsb.2012.04.017. Epub 2012 May 2.
2012
|
| 36 | ATP7A, VCP
|
| Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy.
|
| Yi L, Donsante A, Kennerson ML, Mercer JF, Garbern JY, Kaler SG.
|
| Hum Mol Genet 21(8):1794-807. doi: 10.1093/hmg/ddr612. Epub 2011 Dec 30.
2012
|
| 37 | TRIM21, VCP
|
| AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
|
| Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC.
|
| Proc Natl Acad Sci U S A 109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22.
2012
|
| 38 | ASPSCR1, VCP
|
| The ubiquitin regulatory X (UBX) domain-containing protein TUG regulates the p97 ATPase and resides at the endoplasmic reticulum-golgi intermediate compartment.
|
| Orme CM, Bogan JS.
|
| J Biol Chem. Feb 24;287(9):6679-92. doi: 10.1074/jbc.M111.284232. Epub 2011 Dec 29 2012
|
| 39 | EEA1, VCP
|
| The p97 ATPase associates with EEA1 to regulate the size of early endosomes.
|
| Ramanathan HN, Ye Y.
|
| Cell Res ell Res. 2011 May 10. [Epub ahead of print]
2011
|
| 40 | ATXN3, VCP
|
| The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
|
| Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T.
|
| Nat Cell Biol 13(3):273-81. Epub 2011 Feb 13.
2011
|
| 41 | UBXN6, VCP
|
| Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.
|
| Ritz D, Vuk M, Kirchner P, Bug M, Schütz S, Hayer A, Bremer S, Lusk C, Baloh RH, Lee H, Glatter T, Gstaiger M, Aebersold R, Weihl CC, Meyer H.
|
| Nat Cell Biol 13(9):1116-23. doi: 10.1038/ncb2301.
2011
|
| 42 | DERL1, DERL2, DERL3, ROMO1, SELENOK, SELENOS, VCP
|
| Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis.
|
| Shchedrina VA, Everley RA, Zhang Y, Gygi SP, Hatfield DL, Gladyshev VN.
|
| J Biol Chem 286(50):42937-48. doi: 10.1074/jbc.M111.310920. Epub 2011 Oct 20. 2011
|
| 43 | NSFL1C, VCP, VCPIP1
|
| Isolation of a point-mutated p47 lacking binding affinity to p97ATPase.
|
| Kaneko Y, Tamura K, Totsukawa G, Kondo H.
|
| FEBS Lett 584(18):3873-7. doi: 10.1016/j.febslet.2010.07.061. Epub 2010 Aug 6.
2010
|
| 44 | UBXN6, VCP
|
| UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation.
|
| Nagahama M, Ohnishi M, Kawate Y, Matsui T, Miyake H, Yuasa K, Tani K, Tagaya M, Tsuji A.
|
| Biochem Biophys Res Commun 382(2):303-8. Epub 2009 Mar 9.
2009
|
| 45 | UBXN6, VCP
|
| UBXD1 binds p97 through two independent binding sites.
|
| Kern M, Fernandez-Sáiz V, Schäfer Z, Buchberger A.
|
| Biochem Biophys Res Commun 380(2):303-7. Epub 2009 Jan 25.
2009
|
| 46 | IBMPFD, VCP
|
| Hereditary inclusion body myopathy-linked p97/VCP mutations in the NH2 domain and the D1 ring modulate p97/VCP ATPase activity and D2 ring conformation.
|
| Halawani D, LeBlanc AC, Rouiller I, Michnick SW, Servant MJ, Latterich M.
|
| Mol Cell Biol 29(16):4484-94. Epub 2009 Jun 8.PMID: 19506019 2009
|
| 47 | SFTPC, TMEM67, VCP
|
| Meckel-Gruber syndrome protein MKS3 is required for endoplasmic reticulum-associated degradation of surfactant protein C.
|
| Wang M, Bridges JP, Na CL, Xu Y, Weaver TE.
|
| J Biol Chem 284(48):33377-83. doi: 10.1074/jbc.M109.034371. Epub 2009 Oct 8. 2009
|
| 48 | VCP, YOD1
|
| The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
|
| Ernst R, Mueller B, Ploegh HL, Schlieker C.
|
| Mol Cell 36(1):28-38. doi: 10.1016/j.molcel.2009.09.016.
2009
|
| 49 | VCP, IBMPFD
|
| Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia.
|
| Kimonis VE, Mehta SG, Fulchiero EC, Thomasova D, Pasquali M, Boycott K, Neilan EG, Kartashov A, Forman MS, Tucker S, Kimonis K, Mumm S, Whyte MP, Smith CD, Watts GD.
|
| Am J Med Genet A 146(6):745-57. 2008
|
| 50 | DERL1, VCP
|
| Derlin-1 and p97/valosin-containing protein mediate the endoplasmic reticulum-associated degradation of human V2 vasopressin receptors.
|
| Schwieger I, Lautz K, Krause E, Rosenthal W, Wiesner B, Hermosilla R.
|
| Mol Pharmacol 73(3):697-708. Epub 2007 Nov 29. 2008
|
| 51 | UBXN7, VCP
|
| UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
|
| Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ.
|
| Cell 134(5):804-16. 2008
|
| 52 | UBXN6, VCP
|
| Ubxd1 is a novel co-factor of the human p97 ATPase.
|
| Madsen L, Andersen KM, Prag S, Moos T, Semple CA, Seeger M, Hartmann-Petersen R.
|
| Int J Biochem Cell Biol 40(12):2927-42. Epub 2008 Jul 5.
2008
|
| 53 | VCP, IBMPFD
|
| APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD).
|
| Mehta SG, Watts GD, Adamson JL, Hutton M, Umberger G, Xiong S, Ramdeen S, Lovell MA, Kimonis VE, Smith CD.
|
| Genet Med 9(1):9-13. 2007
|
| 54 | VCP, IBMPFD
|
| Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
|
| Watts GD, Thomasova D, Ramdeen SK, Fulchiero EC, Mehta SG, Drachman DA, Weihl CC, Jamrozik Z, Kwiecinski H, Kaminska A, Kimonis VE.
|
| Clin Genet 72(5):420-6. 2007
|
| 55 | AURKB, VCP
|
| Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
|
| Ramadan K, Bruderer R, Spiga FM, Popp O, Baur T, Gotta M, Meyer HH.
|
| Nature 450(7173):1258-62. 2007
|
| 56 | IBMPFD, VCP
|
| Pathological consequences of VCP mutations on human striated muscle.
|
| Hübbers CU, Clemen CS, Kesper K, Böddrich A, Hofmann A, Kämäräinen O, Tolksdorf K, Stumpf M, Reichelt J, Roth U, Krause S, Watts G, Kimonis V, Wattjes MP, Reimann J, Thal DR, Biermann K, Evert BO, Lochmüller H, Wanker EE, Schoser BG, Noegel AA, Schröder R.
|
| Brain 130(Pt 2):381-93. Epub 2006 Sep 19.
2007
|
| 57 | FTLD, TARDBP, VCP
|
| TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.
|
| Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS.
|
| J Neuropathol Exp Neurol 66(2):152-7.
2007
|
| 58 | IBMPFD, VCP
|
| Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations.
|
| Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD, Markesbery WR, Smith CD, Kimonis VE.
|
| J Neuropathol Exp Neurol 65(6):571-81.
2006
|
| 59 | VCP, IBMPFD
|
| Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation.
|
| Weihl CC, Dalal S, Pestronk A, Hanson PI.
|
| Hum Mol Genet 15(2):189-99. Epub 2005 Dec 1. 2006
|
| 60 | ATXN3, VCP
|
| Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
|
| Zhong X, Pittman RN.
|
| Hum Mol Genet 15(16):2409-20. Epub 2006 Jul 5. 2006
|
| 61 | UBXN2B, VCP
|
| p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis.
|
| Uchiyama K, Totsukawa G, Puhka M, Kaneko Y, Jokitalo E, Dreveny I, Beuron F, Zhang X, Freemont P, Kondo H.
|
| Dev Cell 11(6):803-16.
2006
|
| 62 | VCP, FAF1
|
| Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway.
|
| Song EJ, Yim SH, Kim E, Kim NS, Lee KJ.
|
| Mol Cell Biol 25(6):2511-24. 2005
|
| 63 | VCP, IBMPFD
|
| Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein.
|
| Watts GD, Wymer J, Kovach MJ, Mehta SG, Mumm S, Darvish D, Pestronk A, Whyte MP, Kimonis VE.
|
| Nat Genet 36(4):377-81. Epub 2004 Mar 21. 2004
|
| 64 | DERL1, SELENOS, VCP
|
| A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.
|
| Ye Y, Shibata Y, Yun C, Ron D, Rapoport TA.
|
| Nature 429(6994):841-7. 2004
|
| 65 | DERL1, SELENOS, VCP
|
| A membrane protein required for dislocation of misfolded proteins from the ER.
|
| Lilley BN, Ploegh HL.
|
| Nature 429(6994):834-40. 2004
|
| 66 | AP1S1, ATP6V1D, BM22, CASP8AP2, CDC16, CDC27, CENPE, CLDN16, CMTM4, CYTH3, DDX5, DHX8, EIF3A, EIF3H, EIF4A3, GALNT5, ITPR1, KIF11, KPNB1, LSM6, MFAP1, NCAPD3, NCAPG2, RBM19, RRM2, SART1, SNRPA1, SNRPB, SNW1, SPC25, VCP, ZDHHC5
|
| An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division.
|
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