| Symbol
| ALS14
|
| Location
| 9p13.3
|
| Name
|
amyotrophic lateral sclerosis 14, with or without frontotemporal dementia |
| Corresponding gene
|
VCP
|
| Main clinical features
|
fatal neurodegenerative disease characterized by upper and lower motor neuron dysfunction resulting in rapidly progressive paralysis and death from respiratory failure
may be associated with frontotemporal dementia (FTD) |
| Genetic determination
| autosomal dominant |
| Prevalence
| VCP mutations arise in approximately 1.5p 100 of FALS cases (PMID: 23152587)
|
| Function/system disorder
| neuromuscular |
| Type
| disease
|