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FLASH GENE
Symbol USP3 contributors: mct/npt - updated : 16-03-2010
HGNC name ubiquitin specific peptidase 3
HGNC id 12626
Location 15q22.31      Physical location : 63.796.809 - 63.883.659
Synonym name
  • ubiquitin specific protease 3
  • ubiquitin-specific-processing protease 3
  • ubiquitin thioesterase 3
  • Synonym symbol(s) EVI98, MGC129878, MGC129879, SIH003, UBP
    EC.number 3.1.2.15
    DNA
    TYPE functioning gene
    STRUCTURE 86.85 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC145741 15q21.3 hypothetical LOC145741 LOC390591 15 similar to nucleophosmin LOC388125 15 similar to hypothetical LOC237397 FLJ38723 15q21.3 hypothetical protein FLJ38723 TLN2 15q15-q21 talin 2 LOC390592 15 similar to TSH receptor suppressor element-binding protein-1; TSEP-1 TPM1 15q22.1 tropomyosin 1 (alpha) LACTB 15q22.1 lactamase, beta RPS27L 15q21.3 ribosomal protein S27-like LOC51762 PSFL 15q22.1 anterior pharynx defective 1B-like LOC388126 15 LOC388126 FLJ20151 15q22.1 hypothetical protein FLJ20151 CA12 15q22 carbonic anhydrase XII USP3 15q22.3 ubiquitin specific protease 3 LOC390593 15 similar to RIKEN cDNA 1110004B15 HERC1 15q22 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 DAPK2 15q22.1 death-associated protein kinase 2 FLJ22875 15q22.1 hypothetical protein FLJ22875 SNX1 15q22-q23 sorting nexin 1 SNX22 20q12-13.1 sorting nexin 22 PPIB 15q21-q22 peptidylprolyl isomerase B (cyclophilin B) CSNK1G1 15q22.1-q22.31 casein kinase 1, gamma 1 KIAA0101 15q22.1 casein kinase 1, gamma 1 TRIP4 15q22.1 thyroid hormone receptor interactor 4 KIAA0295 15q21.3-q22.1 thyroid hormone receptor interactor 4 OAZ2 15q22 ornithine decarboxylase antizyme 2 RBPMS2 15q22.1 RNA-binding protein with multiple splicing 2 FLJ22692 15q22.1 hypothetical protein FLJ22692 pp9099 15q22.1 PH domain-containing protein LOC348094 15q22.2 hypothetical protein LOC348094 ACP33 15q21-q22 hypothetical protein LOC348094 MtFMT 15q22.2 methionyl-tRNA formyltransferase, mitochondrial OSTbeta 15q22.2 organic solute transporter beta RIS LOC390594 15 similar to RIKEN cDNA C230080I20 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 2345 - 520 - Nicassio (2007)
    - - 2300 - - ubiquitous, highly in pancreas -
    - polyA site 5800 - - ubiquitous, highly in pancreas -
    - polyA site 4000 - - ? -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase C19 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ubiquitin specific protease
  • cleaving a ubiquitin-proline bond
  • only the second known ubiquitin-specific protease capable of efficiently cleaving a ubiquitin-proline bond (Sloper-Mould 1999)
  • implicated as a novel chromatin modifier in the maintenance of genome integrity (Nicassio 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS