Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

USP3

contributors: mct/npt - updated : 16-03-2010

HGNC name	ubiquitin specific peptidase 3
HGNC id	12626

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q22.31      Physical location : 63.796.809 - 63.883.659
Synonym name	ubiquitin specific protease 3
	ubiquitin-specific-processing protease 3
	ubiquitin thioesterase 3
Synonym symbol(s)	EVI98, MGC129878, MGC129879, SIH003, UBP
EC.number	3.1.2.15

DNA

TYPE	functioning gene
STRUCTURE	86.85 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006537 15 - 2345 NP_006528 - 520 - Nicassio (2007) variant 2 - - 2300 isoform 2 - - ubiquitous, highly in pancreas - variant 3 - polyA site 5800 isoform 3 - - ubiquitous, highly in pancreas - variant 4 - polyA site 4000 isoform 4 - - ? -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY	deubiquitin family
	peptidase C19 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	ubiquitin specific protease
	cleaving a ubiquitin-proline bond
	only the second known ubiquitin-specific protease capable of efficiently cleaving a ubiquitin-proline bond (Sloper-Mould 1999)
	implicated as a novel chromatin modifier in the maintenance of genome integrity (Nicassio 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS