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FLASH GENE
Symbol USP3 contributors: mct/npt - updated : 16-03-2010
HGNC name ubiquitin specific peptidase 3
HGNC id 12626
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • deubiquitin family
  • peptidase C19 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • ubiquitin specific protease
  • cleaving a ubiquitin-proline bond
  • only the second known ubiquitin-specific protease capable of efficiently cleaving a ubiquitin-proline bond (Sloper-Mould 1999)
  • implicated as a novel chromatin modifier in the maintenance of genome integrity (Nicassio 2007)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS