Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol UQCRB contributors: - updated : 06-03-2006
HGNC name ubiquinol-cytochrome c reductase binding protein
HGNC id 12582
Corresponding disease
CMP3D complex III mitochondrial deficiency
Location 8q22      Physical location : 97.239.309 - 97.247.862
Synonym symbol(s) QPC, UQBP, QP-C, UQBC, UQPC
EC.number 1.10.2.2
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
CDH17 8q22.1 cadherin 17, LI cadherin (liver-intestine) GEM 8q22.3 GTP binding protein overexpressed in skeletal muscle LOC392252 8 similar to ribosomal protein S4, X-linked RAD54B 8q21.3-q22 similar to ribosomal protein S4, X-linked FSBP 8q22.1 fibrinogen silencer binding protein DKFZP434I116 8q22.1 DKFZP434I116 protein FLJ20171 8q22.1 hypothetical protein FLJ20171 LOC286148 8q22.1 hypothetical protein LOC286148 FLJ20530 8q22.1 hypothetical protein FLJ20530 CCNE2 8q22.1 cyclin E2 LOC392253 8 similar to Ac2-210 TP53INP1 8q22 tumor protein p53 inducible nuclear protein 1 MGC40214 8q22.1 hypothetical protein MGC40214 PLEKHF2 8q22.1 pleckstrin homology domain containing, family F (with FYVE domain) member 2 LOC157657 8q22.1 hypothetical protein LOC157657 LOC392254 8 similar to glyceraldehyde-3-phosphate dehydrogenase LOC392255 8 similar to growth and differentiation factor 6 UQCRB 8q22 ubiquinol-cytochrome c reductase binding protein CGI-12 8q22.1 CGI-12 protein PTDSS1 8q22 phosphatidylserine synthase 1 SDC2 8q22-q23 syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) PGCP 8q22.2 plasma glutamate carboxypeptidase KIAA1750 8q22.1 KIAA1750 protein LOC286150 8q22.1 similar to 40S ribosomal protein S2 LYRIC 8q22.1 LYRIC/3D3 LAPTM4B 8q22.1 lysosomal associated protein transmembrane 4 beta LOC389678 8 similar to hypothetical protein LOC51249 RPS23P1 8q23 ribosomal protein S23 pseudogene 1 MATN2 8q22 matrilin 2 RPL30 8q22-q24 ribosomal protein L30 FLJ39553 8q22.2 hypothetical protein FLJ39553 UK114 8q22 hypothetical protein FLJ39553 POP1 8q22.1 processing of precursors 1
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Uqcrb
Homologene
FAMILY ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION involved in redox-linked proton pumping
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS electron transport
PATHWAY
metabolism energetic
signaling
mitochondrial respiratory chain
a component
  • complex III of mitochondrial respiratory chain, oxidative phosphorylation (OXPHOS)
  • component of cytochrome bc1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein ubiquinol binding
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS