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FLASH GENE
Symbol UQCRB contributors: - updated : 06-03-2006
HGNC name ubiquinol-cytochrome c reductase binding protein
HGNC id 12582
Corresponding disease
CMP3D complex III mitochondrial deficiency
Location 8q22      Physical location : 97.239.309 - 97.247.862
Synonym symbol(s) QPC, UQBP, QP-C, UQBC, UQPC
EC.number 1.10.2.2
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Uqcrb
Homologene
FAMILY ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
basic FUNCTION involved in redox-linked proton pumping
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS electron transport
PATHWAY
metabolism energetic
signaling
mitochondrial respiratory chain
a component
  • complex III of mitochondrial respiratory chain, oxidative phosphorylation (OXPHOS)
  • component of cytochrome bc1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein ubiquinol binding
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) CMP3D
    related resource MITOP database
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS