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FLASH GENE

Symbol

UQCRB

contributors: mct - updated : 24-11-2020

HGNC name	ubiquinol-cytochrome c reductase binding protein
HGNC id	12582

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	12.59 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006294 4 - 8459 NP_006285 13.4 111 - 1996 8751380 NM_001254752 5 - 8596 NP_001241681 - 140 - 1996 8751380 NM_001199975 5 - 8573 NP_001186904 - 79 - 1996 8751380

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver         Nervous brain         Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

ortholog to murine Uqcrb

Homologene

FAMILY

ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex)

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	involved in redox-linked proton pumping
	plays a crucial role in hypoxia-induced angiogenesis via mitochondrial reactive oxygen species (ROS)-mediated signaling
	potential key roles of UQCRB in angiogenesis and mitochondria-mediated metabolic disorders

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

energetic

signaling

mitochondrial respiratory chain

a component	complex III of mitochondrial respiratory chain, oxidative phosphorylation (OXPHOS)
	component of cytochrome bc1

INTERACTION

DNA

RNA

small molecule

protein	ubiquinol binding
	mitochondrial UQCRB positively regulates KDR signaling in Endothelial cells
	critical role of ELAVL1 in regulating lipid transport and ATP synthesis, by regulating the splicing of APOB mRNA and the translation of UQCRB and NDUFB6

cell & other

REGULATION

activated by

thyroid hormones

ASSOCIATED DISORDERS

corresponding disease(s)

CMP3D

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function inhibits the cancer stem cell-like properties in glioblastoma cells

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma UQCRB and its inhibitors could be a new therapeutic target and lead compounds for eliminating cancer stem cells in glioblastoma cancer angiogenesis   mitochondrial UQCRB modulators are promising antiangiogenic agents

ANIMAL & CELL MODELS